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Faculty

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Alison J. Frontier

  • Professor of Chemistry

PhD, Columbia University, 1999

414 Hutchison Hall
(585) 275-2568
frontier@chem.rochester.edu

Website


Research Overview

The Frontier laboratory is engaged in synthetic organic chemistry research, especially cyclization reactions that produce unusual, densely functionalized ring systems from simple precursors. Research directions being pursued in the lab include the study of novel pericyclic reactions, cationic rearrangements and diastereoselective cyclization cascades, and their application to complex molecule synthesis.

Recent Publications

Connor Holt, Georgios Alachouzos, Alison J. Frontier Leveraging the Halo-Nazarov Cyclization for the Chemodivergent Assembly of Functionalized Haloindenes and Indanones Journal of the American Chemical Society, 2019 https://doi.org/10.1021/jacs.9b00198

Dylan E. Parsons, Alison J. Frontier Noncanonical Cation−π Cyclizations of Alkylidene β-Ketoesters: Synthesis of Spiro-fused and Bridged Bicyclic Ring Systems Organic Letters, 2019 https://doi.org/10.1021/acs.orglett.9b00094

Carlsen, P.N., Stoutenburg, E.G., Frontier, A.J. SYNTHESIS-SYNLETT Lecture: Toward the Asymmetric Synthesis of Tetrapetalone A: Preparation of an Enantioenriched Indane Intermediate and Strategy for Endgame Glycosylation Synthesis (Germany), 2018 https://doi.org/10.1055/s-0036-1591747

Georgios Alachouzos, Alison J. Frontier Cationic Cascade for Building Complex Polycyclic Molecules from Simple Precursors: Diastereoselective Installation of Three Contiguous Stereogenic Centers in a One-Pot Process Journal of the American Chemical Society, 2018 https://doi.org/10.1021/jacs.8b11713

Alachouzos, G., Frontier, A.J. Diastereoselective Construction of Densely Functionalized 1-Halocyclopentenes Using an Alkynyl Halo-Prins/Halo-Nazarov Cyclization Strategy Angewandte Chemie - International Edition, 2017 https://doi.org/10.1002/anie.201709482

Huang, Y.-W., Frontier, A.J. Nazarov Cyclization/Internal Redox Cyclization Sequence for the Synthesis of N-Heterocyclic Bridged Ring Systems Organic Letters, 2016 https://doi.org/10.1021/acs.orglett.6b02369

Huang, Y.-W., Frontier, A.J. Enantioselective Nazarov cyclization catalyzed by a cinchona alkaloid derivative Tetrahedron Letters, 2015 https://doi.org/10.1016/j.tetlet.2014.12.136

Carlsen, P.N., Jiang, C., Herrick, I.R., Frontier, A.J. Studies toward the AB ring system of the tetrapetalone natural products Tetrahedron, 2015 https://doi.org/10.1016/j.tet.2015.05.021

Leboeuf, D., Ciesielski, J., Frontier, A.J. Erratum: Gold(I)-catalyzed iodination of arenes (Synlett (2014) 25 (399)) Synlett, 2015 https://doi.org/10.1055/s-0034-1380682

Vaidya, T., Cheng, R., Carlsen, P.N., Frontier, A.J., Eisenberg, R. Cationic cyclizations and rearrangements promoted by a heterogeneous gold catalyst Organic Letters, 2014 https://doi.org/10.1021/ol403542k

For more, please visit my ORCID Profile