The Spotlight series was created in 2009 as a way of building camaraderie in our department and as a way of communicating our unique departmental culture to prospective students and visitors. Featuring current graduate students, postdoctoral associates, technical staff, and administrative staff it showcases the broad interests and talent of our many department members. In April of 2015, we launched our first online version.
I work in the Gorbunova lab, so my general interests lie in aging. Now, there are many different aspects to this generalized process, so I have to narrow my focus when asking questions about aging organisms. So I focus on the epigenetic components of aging organisms. I am particularly interested in histones, the proteins that form the primary organizational unit of DNA organization (the nucleosome). These proteins have several isoforms, variants, and post-translational modifications that seem to change during aging processes. These affect DNA organization and chromatin overall. If I had to summarize what I study in one sentence, though, I would say that I am interested in how a long-lived rodent species, the naked mole rat, maintains its epigenetic memory during aging processes compared to short-lived species, such as the mouse.
I am currently working in the Werren Lab as a lab technician so apart from working to keep the lab going, I am working on finding the genetic differences in learning and aggregation behavior in Nasonia, a kind of wasp.
I work in the Samuelson Lab, where we study aging and longevity in C.elegans. I’m personally researching SUMOylation modification of transcription factors with respect to aging through the heat shock response pathway. I’m also looking at the accumulation of methylation marks at stress loci in conjunction with SUMO modification as a barrier switch function.
I work in the Ghaemmaghami Lab. We utilize mass spectrometry-based techniques to investigate protein homeostasis. In particular, I study the conservation of protein turnover to understand the relationship between protein turnover and aging.
Broadly, I am interested in how cells behave in the context of tissues and how cells act collectively to build and maintain tissue structures. In the Bergstralh Lab, we’ve found that cells in some tissues break a decades-old rule of cell biology: their shape doesn’t dictate the direction in which they divide. I have been working to understand how and why this rule is being broken.
I am the Course Coordinator for the Undergraduate Program. My primary duties include providing instructors with Blackboard, classroom, and exam support. I also provide coordination and support for approximately 90 teaching assistants per semester, manage student enrollment, and function as the department liaison to the Registrar’s office.
Our lab investigates the molecular mechanisms behind aging and cancer in a variety of unique species like the adorable Naked Mole Rat. These little guys live an exceptionally long time for rodents and are extremely resistant to cancer.
Our lab looks at tissue morphogenesis and tissue development. I am using mouse intestinal organoids as a model system to look at how cell division influences tissue shape in this system.
My current research in the Welte Lab focuses on understanding how lipids are involved in regulating nuclear histone accumulation during early embryogenesis.
Currently, I am working to understand the role of putative human tRNA modification enzymes in vivo and how defects in proper modification status can cause human disorders.
I am comparing naked mole rat blood and skin stem cells to those of wild type BL6 mice, rats, and a mouse model overexpressing Hyaluronic Acid Synthase 2 to find new mechanisms of sustained stem cell function at a higher age.