The Kennedy Research Group at the University of Rochester, Department of Chemistry is pioneering mechanistically-informed design of next-generation catalysts and catalyst-control strategies that harness earth-abundant elements to redefine sustainable organic synthesis. Our approach is distinguished by innovation at the inorganic-organic interface, where we leverage deep-dive mechanistic investigations and draw inspiration from universal reactivity principles to transcend the limitations of current state-of-the-art methods in molecular catalysis. By seamlessly integrating mechanistic discovery with reaction innovation, we aim to unlock groundbreaking transformations and uncover unexpected principles that open entirely new directions in synthesis and catalysis.