Engineered Metallobiomolecules for Energy Conversion
Developing sustainable energy sources is a major challenge facing humanity. Among alternative fuels, hydrogen (H2) is attractive because it is energy-dense and carbon-free. To be truly
Manganese Porphyrins as MRI Contrast Agents
Manganese porphyrins are effective MRI contrast agents with lower toxicity than gadolinium. Furthermore, they display enhanced relaxivity at higher magnetic field, behavior that is the opposite of gadolinium agents. In collaboration with Xiao-an Zhang of the University of Toronto, we are employing NMR to investigate the electronic structure of manganese porphyrin contrast agents to understand factors that impact their relaxivity
Heme Protein Dynamics and Electronic Structure
Proteins undergo conformational fluctuations on a range of
Cytochrome c Folding
Protein folding is characterized by a large degree of heterogeneity. We are working toward characterizing the complex process of protein folding in terms of conformational and mechanistic complexity. Conformational changes of cytochrome c are of biological interest because of the relevance to its role in apoptosis.