2023
Hydrogen evolution catalysis by a cobalt porphyrin peptide: A proposed role for porphyrin propionic acid groups. Jose L Alvarez-Hernandez, Alison A. Salamatian, Andrew E. Sopchak, Kara L. Bren. Journal of Inorganic Biochemistry. 2023 DOI:https://doi.org/10.1016/j.jinorgbio.2023.112390
Shewanella oneidensis MR-1 respire CdSe quantum dots for photocatalytic hydrogen production. Emily H. Edwards, Jana Jelušić, Ryan M. Kosko, Soraya S. Ngarnim, Wesley Chiang, Sanela Lampa-Pastirk, Todd D. Krauss, Kara L. Bren. PNAS. 2023 DOI:https://doi.org/10.1073/pnas.220697512
2022
Potential- and Buffer-Dependent Selectivity for the conversion of CO2 to CO by a Cobalt Porphyrin-Peptide Electrocatalyst in Water. Jose L. Alvarez-Hernandez, Alison A. Salamatian, Ji Won Han, Kara L. Bren. ACS Catal. 2022 DOI: https://doi.org/10.1021/acscatal.2c03297
Bioinspired and biomolecular catalysts for energyconversion and storage. Alison A. Salamatian, Kara L. Bren. FEBS Letters. 2022 DOI: https://doi.org/10.1002/1873-3468.14533
A cobalt mimochrome for photochemical hydrogen evolution from neutral water, Emily H. Edwards, Jennifer M. Le, Alison A. Salamatian, Noelle L. Peluso, Lnda Leone, Angela Lombardi, Kara L. Bren. J. Inorg. Biochem. 2022 DOI: https://doi.org/10.1016/j.jinorgbio.2022.111753
2021
The two redox states of the human NEET proteins' [2Fe-2S] clusters, Ke Zuo, Henri-Baptiste Marjault, Kara L. Bren, Giulia Rossetti, Rachel Nechushtai and Paolo Carlonic. J. Biol. Inorg. Chem. 2021. DOI: https://doi.org/10.1007/s00775-021-01890-8
Contributions to cytochrome c inner- and outer-sphere reorganization energy,
Linear Free Energy Relationships in Hydrogen Evolution Catalysis by a Cobalt Tripeptide in Water, Jose L. Alvarez-Hernandez, Ji Won Han, Andrew E. Sopchak, Yixing Guo, and Kara L. Bren. ACS Energy Lett. 2021. DOI: https://doi.org/10.1021/acsenergylett.1c00680
Photochemical hydrogen evolution from cobalt microperoxidase-11, Emily H. Edwards, Jana Jelušić, Saikat Chakraborty, and Kara L. Bren. J. Inorg. Biochem.2021. DOI: https://doi.org/10.1016/j.jinorgbio.2021.111384
Light-driven hydrogen production with CdSe quantum dots and a cobalt glutathione catalyst, Rebeckah Burke, Saikat Chakraborty, Kevin P. McClelland, Jana Jelušić, Ellen M. Matson, Todd D. Krauss, and Kara L. Bren, Chem. Comm.2021. DOI: https://doi.org/10.1039/D0CC07364D
Semiconductor nanocrystal photocatalysis for the production of solar fuels, J. Chem. Phys. 2021. DOI: https://doi.org/10.1063/5.0032172
2020
Electrocatalytic Multielectron Nitrite Reduction in Water by an Iron Complex, Jesse R. Stroka, Banu Kandemir, Ellen M. Matson, and Kara L. Bren. ACS Catal. 2020. DOI: https://pubs.acs.org/doi/10.1021/acscatal.0c03600
Hydrogen bonding promotes diversity in nitrite coordination modes at a single iron(II) center, D. M. M. Mevan Dissanayake, Brittney E. Petel, William W. Brennessel, Kara L. Bren and Ellen M. Matson. J. Coord. Chem. 2020. DOI: https://doi.org/10.1080/00958972.2020.1821373
Enhancing the activity of photocatalytic hydrogen evolution from CdSe quantum dots with a polyoxovanadate cluster, Emily H. Edwards, Alex A. Fertig, Kevin P. McClelland, Mahilet T. Meidenbauer, Saikat Chakraborty, Todd D. Krauss, Kara L. Bren, and Ellen M. Matson. Chem. Comm. 2020. DOI: https://doi.org/10.1039/D0CC03163A
Light-driven catalysis with engineered enzymes and biomimetic systems, Emily H. Edwards, and Kara L. Bren. Biotechnol. Appl. Biochem. 2020. DOI: https://doi.org/10.1002/bab.1976
Buffer pKa Impacts the Mechanism of Hydrogen Evolution Catalyzed by a Cobalt Porphyrin-peptide, Jose L. Alvarez-Hernandez, Andrew Sopchak, and Kara L. Bren. Inorg. Chem. 2020. DOI: https://doi/10.1021/acs.inorgchem.0c00362
Tuning Mechanism through Buffer Dependence of Hydrogen Evolution Catalyzed by a Cobalt Mini-Enzyme, Jennifer M. Le, Georgios Alachouzos, Marco Chino, Alison J. Frontier, Angela Lombardi, and Kara L. Bren. Biochemistry. 2020. DOI: https://doi.org/10.1021/acs.biochem.0c00060
2019
Photochemical Hydrogen Evolution from Neutral Water with a Cobalt Metallopeptide Catalyst, Saikat Chakraborty, Emily H. Edwards, Banu Kandemir, and Kara L. Bren. Inorg. Chem. 2019. DOI: 10.1021/acs.inorgchem.9b02067
Engineered Enzymes and Bioinspired Catalysts for Energy Conversion, Jennifer M. Le and Kara L. Bren. ACS Energy Lett. 2019. DOI: 10.1021/acsenergylett.9b01308 (Selected as ACS Editor's Choice and ACS Energy Letters Energy Selects: https://pubs.acs.org/doi/10.1021/acsenergylett.9b01883)
2018
A Cobalt Metallopeptide Electrocatalyst for the Selective Reduction of Nitrite to Ammonium, Yixing Guo, Jesse R. Stroka, Banu Kandemir, Claire E. Dickerson, Kara L. Bren. J. Am. Chem. Soc. 2018. DOI: 10.1021/jacs.8b09612
Hydrogen Evolution from Water by Cobalt-Mimochrome VI*a, a Synthetic Mini-Protein, Vincenzo Firpo, Jennifer M. Le, Vincenzo Pavone, Angela Lombardi, Kara L. Bren, Chem Sci. 2018. DOI: 10.1039/C8SC01948G
Beyond Fossil Fuel-Driven Nitrogen Transformations, Jinguan G. Chen, Richard M. Crooks, Lance Seefeldt, Kara L. Bren, R. Morris Bullock, Marcetta Y. Darensbourg, Patrick L. Holland, Brian Hoffman, Michael J. Janik, Anne K. Jones, Mercouri Kanatzidis, Paul King, Kyle M. Lancaster, Sergei Lymar, Peter Pfromm, Willam F. Schneider, Richard R. Schrock, Science. 2018. DOI: 10.1126/science.aar6611
Influence of Heme c Attachment on Heme Conformation and Potential, Jesse K. Kleingardner, Benjamin D. Levin, Giorgio Zoppellaro, Kristoffer Andersson, Sean J. Elliot, Kara L. Bren, J. Biol. Inorg. Chem. 2018. DOI: 10.1007/s00775-1018-1603-3.
Carbene Capture in a Myoglobin Mutant, Emily H. Edwards and Kara L. Bren. Nat Catalysis. 2018. DOI: 10.1038/s41929-018-0129-y.
2017
Covalent Bonding of Heme to Protein Prevents Heme Capture by Nontypeable Haemophilus
Engineered Biomolecular Catalysts. Kara L. Bren. J. Am. Chem. Soc. 2017. DOI: 10.1021/jacs.7b09896.
Locked and Loaded for Apoptosis. Kara L. Bren and Emma L. Raven, Science. 2017. DOI: 10.1126/science.aan5587.
Photoinduced Charge Separation in Single-Walled Carbon Nanotube/Protein Integrated Systems. Lenore Kubie, Amanda R. Amori, Saikat Chakraborty, Kara L. Bren, and Todd. Krauss. Nanoscale Horizons. 2017. DOI: 10.1039/C6NH00172F.
Efficient and Flexible Preparation of Biosynthetic Microperoxidases, Erin C. Kleingardner, Wesley B. Asher, and Kara L. Bren, Biochemistry. 2017. DOI: 10.1021/acs.biochem.6b00915.
2016
Go with the Electron Flow: Effects of Heme Electronic Structure on Electron Transfer, Kara L. Bren. Israel Journal of Chemistry. 2016. DOI: 10.1002/ijch.201600021. Special Issue in Celebration of Harry Gray's 80th Birthday.
Extracellular Electron Transfer on Sticky Paper Electrodes: Microbial Fuel Cell with a Carbon Paste Paper Anode, Peter Lamberg and Kara L. Bren, ACS Energy Letters. 2016. DOI: acsenergylett.6b00435.
NMR Analysis of
Semisynthetic and Biomolecular Hydrogen Evolution Catalysts, Banu Kandemir, Saikat Chakraborty, Yixing Guo
Hydrogen Evolution from Water under Aerobic Conditions Catalyzed by a Cobalt-ATCUN Metallopeptide., Banu Kandemir, Lenore Kubie, Yixing Guo, Brian Sheldon and Kara L. Bren, Inorg. Chem. 2016. DOI: 10.1021/acs.inorgchem.5b02157 (Featured on journal cover).
2015
Discovery of the Magnetic Behavior of Hemoglobin: A Beginning of Bioinorganic Chemistry, Kara L. Bren, Richard Eisenberg, and Harry B. Gray, Proc. Natl. Acad. Sci. U.S.A. 2015. DOI: 10.1073/pnas.1515704112
Biological Significance and Applications of Heme c Proteins and Peptides, Jesse G. Kleingardner, and Kara L. Bren, Acc. Chem. Res., 2015, 48, 1845-1852. DOI: 10.1021/acs.accounts.5b00106
Methionine Ligand Lability of Homologous Monoheme Cytochromes c, Benjamin D. Levin, Kelly A. Walsh, Kristal K. Sullivan, Kara L. Bren, and Sean J. Elliott, Inorg. Chem. 2015. DOI: 10.1021/ic501186h
Effects of Protein Structure on Iron-Polypeptide Vibrational Dynamic Coupling in Cytochrome c, Mary Grace I. Galinato, Sarah E. J. Bowman, Jesse G. Kleingardner, Sherri Martin, Jiyong Zhao, Wolfgang Sturhahn, E. Ercan Alp, Kara L. Bren, and Nicolai Lehnert, Biochemistry. 2015. DOI: 10.1021/bi501430z
Multidisciplinary Approaches to Solar Hydrogen, Kara L. Bren, J. Royal Soc. Interface.
2014
Affinity Purification of Heme-tagged Proteins, Wesley B. Asher, Kara L. Bren, Methods in Molecular Biology, 2014. DOI: 10.1007/978-1-4939-1034-2_2
Hydrogen Evolution from Neutral Water Under Aerobic Conditions Catalyzed by Cobalt-
Investigations of Heme Distortion, Low-Frequency Vibrational Excitations, and Electron Transfer in Cytochrome c.
2013
Redox State Dependence of Axial Ligand Dynamics in Nitrosomonas
The Influence of Heme Ruffling on Spin Densities in
Conformational Change and Human Cytochrome c Function: Mutation of Residue 41 Modulates Caspase Activation and Destabilizes Met-80 Coordination. Tracy M. Josephs, Matthew D. Liptak, Gillian Hughes, Alexandra Lo, Rebecca M. Smith, Sigurd M. Wilbanks, Kara L. Bren, and Elizabeth C. Ledgerwood, J. Biol. Inorg. Chem., 2013. DOI: 10.1007/s00775-012-0973-1
Structural Characterization of Nitrosomonas
Single-molecule Analysis of Cytochrome c Folding by Monitoring the Lifetime of an Attached Fluorescent Probe. Andrea J. Lee, Wesley B. Asher, Harry A. Stern, Kara L. Bren, Todd D. Krauss, J. Phys. Chem. Lett., 2013. DOI: 10.1021/jz401259y
2012
Heme-Protein Vibrational Couplings in Cytochrome c Provide a Dynamic Link that Connects the Heme-Iron and the Protein Surface, Mary Grace I. Galinato, Jesse G. Kleingardner, Sarah E. J. Bowman, E. Ercan Alp, Jiyong Zhao, Kara L. Bren, and Nicolai Lehnert, Proc. Natl. Acad Sci.
Cytochrome c heme lyase can mature a fusion peptide composed of the amino-terminal residues of horse cytochrome c. Wesley B. Asher and Kara L. Bren, Chem Comm., 2012, 48. DOI: 10.1039/c2cc31112g.
NMR Spectroscopy of Paramagnetic Heme Proteins, Kara L. Bren, Current Inorganic Chemistry, 2012. DOI: 10.2174/1877944111202030273
2011
Modulation of Ligand-Field Parameters by Heme Ruffling in Cytochromes c Revealed by EPR Spectroscopy, Mehmet Can, Giorgio Zoppellaro, K. Kristoffer Andersson, Kara L. Bren, Inorg. Chem., 2011. DOI: 10.1021/ic201479q
Methionine Ligand
Comparing substrate specificity between cytochrome c maturation and cytochrome c heme lyase systems for cytochrome c biogenesis, Jesse G. Kleingardner, Kara L. Bren, Metallomics, 2011. DOI: 10.1039/c0mt00086h
Temperature Dependent Equilibrium Native to Unfolded Protein Dynamics and Properties Observed with IR Absorption and 2D IR Vibrational Echo Experiments, Jean K. Chung, Megan C. Thielges, Sarah E. J. Bowman, Kara L. Bren, M. D. Fayer, J. Am. Chem. Soc., 2011. DOI: 10.1021/ja111009s
The Proapoptotic G41S Mutation to Human Cytochrome c Alters the Heme Electronic Structure and Increases the Electron Self-Exchange Rate, Matthew D. Liptak, Robert D. Fagerlund, Elizabeth C. Ledgerwood, Sigurd M. Wilbanks, Kara L. Bren, J. Am. Chem. Soc., 2011. DOI: 10.1021/ja106328k
2010
Zinc Porphyrin as a Donor for FRET in Zinc Cytochrome c, Andrea J. Lee, Amy A. Ensign, Todd D. Krauss, and Kara L. Bren, J. Am. Chem. Soc., 2010. DOI: 10.1021/ja909106p.
NMR and DFT Investigation of Heme Ruffling: Functional Implications for Cytochrome c, Matthew D. Liptak, Xin Wen, and Kara L. Bren, J. Am. Chem. Soc., 2010. DOI: 10.1021/ja102098p.
A Heme Fusion Tag for Protein Affinity Purification and Quantitation, Wesley B. Asher and Kara L. Bren, Protein Science, 2010. DOI: 10.1002/pro.460
Variation and Analysis of Second-sphere Interactions and Axial Histidinate Character in c-type Cytochromes, Sarah E. J. Bowman and Kara L. Bren, Inorg. Chem., 2010. DOI: 10.1021/ic100899k
2009
Studies of Ferric Heme Proteins with Highly Anisotropic/Highly Axial Low Spin (S= 1/2) Electron Paramagnetic Resonance Signals with Two Histidines or Histidine and Methionine Axial Fe Coordination. Giorgio Zoppellaro, Kara L. Bren, Amy A. Ensign, Espen Harbitz, Ravinder Kaur, Hans–Petter Hersleth, Ulf Ryde, Lars Hederstedt, and K. Kristoffer Andersson, Biopolymers, 2009. DOI: 10.1002/bip.21267
2008
Modulation of the Ligand-Field Anisotropy in a Series of Ferric Low-Spin Cytochrome c Mutants derived from Pseudomonas
Methionine Ligand Lability of Type I Cytochromes c: Detection of Ligand Loss Using Protein Film Voltammetry. Tao Ye, Ravinder Kaur, F. Timur Senguen, Lea V. Michel, Kara L. Bren and Sean J. Elliott, J. Am. Chem. Soc., 2008. DOI: 10.1021/ja801071n
Zinc porphyrin: A fluorescent acceptor in studies of Zn-cytochrome c unfolding by fluorescence resonance energy transfer. Amy A. Ensign, Iris Jo, Ilyas Yildirim, Todd D. Krauss, and Kara L. Bren, Proc. Natl. Acad. Sci.
The chemistry and biochemistry of heme c: functional bases for covalent attachment. Sarah E. J. Bowman and Kara L. Bren, Nat. Prod. Rep., 2008. DOI: 10.1039/b717196j
Native and Unfolded Cytochrome c - Comparison of Dynamics using 2D-IR Vibrational Echo Spectroscopy. Seongheun Kim, Jean K. Chung, Kyungwon Kwak, Sarah E. J. Bowman, Kara L. Bren, Biman Bagchi and M. D. Fayer, J. Phys. Chem. B, 2008. DOI: 10.1021/jp802246h
2007
Heme Attachment Motif Mobility Tunes Cytochrome c Redox Potential. Lea V. Michel, Tao Ye, Sarah E. J. Bowman, Benjamin D. Levin, Megan A. Hahn, Brandy S. Russell, Sean J. Elliott, and Kara L. Bren, Biochemistry, 2007. DOI: 10.1021/bi701177j
Effects of Heme Pocket Structure and Mobility on Cytochrome c Stability. Xin Wen, Kirti M. Patel, Brandy S. Russell, and Kara L. Bren, Biochemistry, 2007. DOI: 10.1021/bi602380v
2006
Cytochrome c552 Mutants: Structure and Dynamics at the Active Site Probed by Multidimensional NMR and Vibration Echo Spectroscopy. Aaron M. Massari, Brian L. McClain, Ilya J. Finkelstein, Andrew P. Lee, Heather L. Reynolds, Kara L. Bren, and Michael D. Fayer, J. Phys. Chem. B, 2006. DOI: 10.1021/jp054959q
2005
Redox Properties of Wild-Type and Heme-Binding Loop Mutants of Bacterial Cytochromes
Heme Axial Methionine Fluxion in Pseudomonas
The Influence of Aqueous versus Glassy Solvents on Protein Dynamics: Vibrational Echo Experiments and Molecular Dynamics Simulations. Aaron M. Massari, Ilya J. Finkelstein, Brian L. McClain, Anne Goj, Xin Wen, Kara L. Bren, Roger F. Loring, and Michael D. Fayer, J. Am. Chem. Soc., 2005. DOI: 10.1021/ja053627w
An Obligatory Intermediate in the Folding Pathway of Cytochrome c552 from Hydrogenobacter
Suppression of Axial Methionine Fluxion in Hydrogenobacter
2004
Folding, Conformational Changes, and Dynamics of Cytochromes c Probed by NMR Spectroscopy. Kara L. Bren, Jason A. Kellogg, Ravinder Kaur, and Xin Wen, Inorg. Chem., 2004. DOI: 10.1021/ic048925t
Cytochrome rC552, Formed During Expression of the Truncated, Thermus thermophilusCytochrome c552 Gene in the Cytoplasm of Escherichia coli, Reacts Spontaneously to Form Protein-Bound, 2-Formyl-4-vinyl (Spirographis) Heme. James A. Fee, Thomas R. Todaro, Eugene Luna, Donita Sanders, Laura Hunsicker-Wang, Kirti M. Patel, Kara L. Bren, Ester Gomez-Moran, Michael G. Hill, Jingyuan Ai, Thomas M. Loehr, W. Anthony Oertling, Pamela A. Williams, C. David Stout, Duncan McRee, and Andrzej Pastuszyn, Biochemistry, 2004. DOI: 10.1021/bi048968l
Heme Axial Methionine Fluxionality in Hydrogenobacter
2003
Backbone Dynamics and Hydrogen Exchange of Oxidized Pseudomonas aeruginosaFerricytochrome c551. Brandy S. Russell, Linghao Zhong, Maria Giulia Bigotti, Francesca Cutruzzolà, and Kara L. Bren, J. Biol. Inorg. Chem., 2003. DOI: 10.1007/s00775-002-0401-z
2002
Characterization of Recombinant Horse Cytochrome c Synthesized with the Assistance of Escherichia coli Cytochrome c Maturation Factors. Jason A. Kellogg and Kara L. Bren, Biochim. Biophys. Acta, 2002. DOI: 10.1016/S1570-9639(02)00471-5
Denaturant Dependence of Equilibrium Unfolding Intermediates and Denatured State Structure of Horse Ferricytochrome c. Brandy S. Russell and Kara L. Bren, J. Biol. Inorg. Chem., 2002. DOI: 10.1007/s00775-002-0381-z
Peptide Mimotopes of Pneumococcal Capsular PS of 6B Serotype. A Peptide Mimotope Can Bind to Two Unrelated Antibodies. Jeon-Soo Shin, Jigui Yu, Jisheng Lin, Linghao Zhong, Kara L. Bren, and Moon H. Nahm., J. Immunol., 2002. http://www.jimmunol.org/cgi/reprint/168/12/6273
Characterization of Hydrogenobacter
2001
Recombinant Cytochrome rC557 Obtained from Escherichia coli Cells Expressing a Truncated Thermus
2000
NMR Investigation of Ferricytochrome c Unfolding: Detection of an Equilibrium Unfolding Intermediate and Residual Structure in the Denatured State. Brandy S. Russell, Rory Melenkivitz, and Kara L. Bren, Proc. Natl. Acad. Sci. U.S., 2000. DOI: 10.1073/pnas.150239397