Greg DeAngelis

Greg DeAngelis

  • George Eastman Professor
  • Professor of Brain and Cognitive Sciences
  • Professor of Neuroscience
  • Professor of Biomedical Engineering
  • Professor in the Center for Visual Science

PhD, University of California Berkeley/San Francisco, 1992

321 Meliora Hall
(585) 275-8677

Office Hours: By appointment

Research Overview

My laboratory studies cortical circuits that mediate visual perception and visually guided behavior. This work involves a creative fusion of the disciplines of neurophysiology, psychology, and computation. Monkeys are trained to perform demanding discrimination tasks, and we record from single or multiple neurons in visual cortex during performance of these tasks. This allows us to directly compare the ability of neurons to discriminate between different sensory stimuli with the ability of the behaving animal to make the same discrimination. This approach also allows us to examine the relationship between neuronal activity and perceptual decisions (independent of the physical stimulus). In addition, the techniques of electrical microstimulation and/or reversible inactivation are used to establish causal links between physiology and behavior. Computational modeling plays an important role in interpreting results and guiding future experimentation.

Our research currently has two main foci:

  1. Neural mechanisms of depth perception. The image formed on each retina is a two-dimensional projection of the three-dimensional (3D) world. Objects at different depths project onto slightly disparate points on the two retinas, and the brain is able to extract these binocular disparities from the retinal images and construct a vivid sensation of depth. My lab studies the mechanisms by which binocular disparity information is encoded, processed, and read out by the brain in order to perceive depth and compute 3D surface structure. We are beginning to elucidate the brain areas that contribute to stereoscopic depth perception under specific task conditions, although much remains to be learned about this interesting cognitive process. We have also recently discovered a population of neurons that combines visual motion with eye movement signals to code depth from motion parallax, and future work will focus on how depth cues from disparity and motion parallax are integrated by neurons.
  2. Sensory integration for self-motion perception. To accurately perceive our own motion through space, we integrate information from the visual and vestibular systems. Integrating information across different sensory systems is a fundamental issue in systems neuroscience. Because visual and vestibular signals originate in different spatial frames of reference and with different temporal dynamics, an interesting set of computations must occur in order for these cues to be combined perceptually. Using a 3D virtual reality system to provide monkeys with naturalistic combinations of visual stimuli and inertial motion, we are studying how cortical neurons integrate visual and vestibular signals to compute one's direction of heading through 3D space. We are testing whether the activity of multi-modal neurons in the cortex can account for the changes in perceptual performance that occur when visual and vestibular signals are combined synergistically or placed in conflict. The ultimate goal is to develop a detailed neurobiological account of Bayesian optimal cue integration.

Research Interests

  • 3D vision and navigation
  • Multisensory integration
  • Neural coding
  • Decision-making


  • BCSC 245:  Sensory and Motor Neuroscience

Featured Publications

Selected Publications

For a complete list of publications (via PubMed), click here.

Research Collaborators

Akiyuki Anzai, Research Associate, Brain & Cognitive Sciences

Research Support

The National Eye Institute provides support for this research.

Current Graduate Students & Postdocs

Grad Students

Yelin Dong, Graduate Student


Vitaly Lerner, Postdoctoral Fellow