Publications

2003-present

Nazarov Cyclization/Internal Redox Cyclization Sequence for the Synthesis of N-Heterocyclic Bridged Ring Systems
Huang, Yu-Wen, Frontier, Alison J. “” Org. Lett. 201618, 4896-4899. 

Studies toward the AB ring system of the tetrapetalone natural products
Carlsen, P. N.; Jiang, C.; Herrick, I. R.; Frontier, A. J. Tetrahedron, 2015, 71, 5886–5896 (Invited paper for special issue honoring Barry Trost)

Enantioselective Nazarov cyclization catalyzed by a Cinchona alkaloid derivative
Huang, Yu-Wen; Frontier, A. J. Tetrahedron Lett. 2015, 56, 3523-3526 (Invited paper for special issue honoring Harry Wasserman)

No Acid Required: 4p and 6p Electrocyclization Reactions of Dienyl Diketones for the Synthesis of Cyclopentenones and 2H-Pyrans
Jacob, Steven; Brooks, Joshua L.; Frontier, A. J. J. Org. Chem. 2014, 79, 10296–10302.

Synthesis of (±)-Tetrapetalone A-Me Aglycon
Carlsen, P. N.; Mann, T. J.; Hoveyda, A. H.; Frontier, A. J. Angew Chem. Int. Ed. 2014, 53, 9334-9338

Flavaglines Target Primitive Laukemia Cells and Enhance Anti-Leukemia Drug Activity
Callahan, K.; Minhajuddin, M.; Corbett, C.; Lagadinou, E.; Rossi, R.; Balys, M.; Pan, L.; Jacob, S.; Frontier, A.; Grever, M.; Lucas, D.; Kinghorn, A. D.; Liesveld, J. L.; Becker, M.; Jordan, C. Leukemia, 2014, 28, 1960–1968

The Phomactin Natural Products: From Isolation to Total Synthesis
Ciesielski, J.; Frontier, A. J. J. Org. Prep. Proc. Int., 2014, 46, 214-251

Preparation of 5-Hydroxycyclopentenones via Conjugate Addition-Initiated Nazarov Cyclization
Brooks, J. L.; Huang, Y.-W.; Frontier, A. J. Org. Syn., 2014, 91, 93.

Cationic Cyclizations and Rearrangements Promoted by a Heterogeneous Gold Catalyst
Vaidya, T.; Cheng, R.; Carlsen, P. N.; Frontier, A. J.; Eisenberg, R. Org. Lett., 2014, 16 (3), 800–803

Gold(I)-Catalyzed Iodination of Arenes
Lebœuf, D.; Ciesielski, J.; Frontier, A. J. Synlett, 2014, 25, 399-402.

Gold(III) Chloride-Catalyzed 6-endo-trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones
Ciesielski, J.; Lebœuf, D.; Stern, H. A.; Frontier, A. J. Adv. Synth. Catal., 2013, 355, 2077-2082.

Cascade Cyclizations of Acyclic and Macrocyclic Alkynones: Studies toward the Synthesis of Phomactin A
Ciesielski, J.; Gandon, V.; Frontier, A. J. J. Org. Chem., 2013, 78, 9541-9552. (Featured Article)

Beyond the Divinyl Ketone: Innovations in the Generation and Nazarov Cyclization of Pentadienyl Cation Intermediates
Spencer, W. T. III; Vaidya, T.; Frontier, A. J. Eur. J. Org. Chem., 2013, 18, 3621-3633. Invited Microreview. Top 10 most accessed articles for May 2013

Efficient Nazarov Cyclization/Wagner-Meerwein Rearrangement Terminated by a Cu(II)-Promoted Oxidation: Synthesis of 4-Alkylidene Cyclopentenones
Lebœuf, D.; Theiste, E.; Gandon, V.; Daifuku, S. L.; Neidig, M. L.; Frontier, A. J. Chem. Eur. J., 2013, 19, 4842–4848.

Reagent Control of 1,2-Wagner-Meerwein Shift Chemoselectivity following Nazarov Cyclization: Application to the Total Synthesis of Enokipodin B
Lebœuf, D.; Wright, C. M.; Frontier, A. J. Chem. Eur. J., 2013, 19, 4835–4841.

Cyclization Cascades Initiated by 1,6-Conjugate Addition
Brooks, J. L.; Frontier, A. J. J. Am. Chem. Soc., 2012, 134, 16551-16553.

A Cycloaromatization Protocol for Synthesis of Polysubstituted Phenol Derivatives: Method Development and Mechanistic Studies
Spencer, W. T. III; Frontier, A. J. J. Org. Chem., 2012, 77, 7730–7736.

A Macrocyclic β-Iodoallenolate Intermediate is Key: Synthesis of the ABD Core of Phomactin A
Ciesielski, J.; Cariou, K.; Frontier, A. J. Org. Lett., 2012, 14, 4082-4085.

Experimental and Theoretical Studies on the Nazarov Cyclization/Wagner-Meerwein Rearrangement Sequence
Lebœuf, D.; Ciesielski, J.; Gandon, V.; Frontier, A. J. J. Am. Chem. Soc., 2012, 134, 6296–6308.

Total Synthesis of (±)-Rocaglamide via Oxidation-Initiated Nazarov Cyclization
Malona, J. A.; Cariou, K.; Spencer, W. T. III, Frontier, A. J. J. Org. Chem., 2012, 77, 1891–1908.

Using Nazarov Electrocyclization to Stage Chemoselective [1,2]-Migrations: Stereoselective Synthesis of Functionalized Cyclopentenones
Lebœuf, D.; Huang, J.; Gandon, V.; Frontier, A. J. Angew. Chem., Int. Ed., 2011, 50, 10981-10985.

Conjugate Addition-Initiated Nazarov Cyclization
Brooks, J. L.; Caruana, P. A.; Frontier, A. J. J. Am. Chem. Soc., 2011, 133, 12454-12457.

Catalytic Nazarov Cyclization: The State of the Art
Vaidya, T.; Frontier, A. J.; Eisenberg, R. ChemCatChem, 2011, 3, 1531-1548.

Understanding the fate of the oxyallyl cation following Nazarov electrocyclization: sequential Wagner-Meerwein migrations and the synthesis of spirocyclic cyclopentenones
Huang, J.; Lebœuf, D.; Frontier, A. J. J. Am. Chem. Soc., 2011, 133, 6307-6317.

Divergent Reaction Pathways of a Cationic Intermediate: Rearrangement and Cyclization of 2-Substituted Furyl and Benzofuryl Enones Catalyzed by Iridium(III)
Vaidya, T.; Manbeck, G.; Chen, S.; Frontier, A. J.; Eisenberg, R. J. Am. Chem. Soc., 2011, 113, 3300-3303.

Oxidation-Initiated Nazarov Cyclization of Vinyl Alkoxyallenes
Spencer, W. T. III; Levin, M. D.; Frontier, A. J. Org. Lett., 2011, 13, 414-417

Dicationic Palladium(II) Complexes as Active Lewis Acid Catalysts for Polarized Nazarov Cyclization
Zhang, J.; Vaidya, T.; Brennessel, W. W.; Frontier, A. J.; Eisenberg R. Organometallics, 2010, 29, 3341-3349.

Synthesis, Characterization, and Catalytic Properties of New Electrophilic Iridium(III) Complexes Containing the (R)-(+)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl Ligand
Atesin, A. C.; Zhang, J.; Vaidya, T.; Brennessel, W. W.; Frontier, A. J.; Eisenberg, R. Inorg. Chem., 2010, 49, 4331- 4342.

A Highly Reactive Dicationic Iridium (III) Catalyst for the Polarized Nazarov Cyclization Reaction
Vaidya, T.; Atesin, A. C.; Herrick, I. R.; Frontier, A. J.; Eisenberg, R. Angew. Chem., Int. Ed., 2010, 49, 3363-3366.

β-Iodoallenolates as Springboards for Annulation Reactions
Ciesielski, J.; Canterbury, D. P.; Frontier, A. J. Org. Lett., 2009, 11, 4374-4377.

Nazarov Cyclization Initiated by Peracid Oxidation: The Total Synthesis of (±)-Rocaglamide
Malona, J. A.; Cariou, K.; Frontier, A. J. J. Am. Chem. Soc., 2009, 131, 7560–7561.

Formal Synthesis of Roseophilin
Bitar, A. Y., Frontier, A. J. Org. Lett., 2009, 11, 49-52.

A Torquoselective Extrusion of Isoxazoline N-Oxides. Application to the synthesis of Aryl Vinyl and Divinyl Ketones for Nazarov Cyclization
Canterbury, D. P.; Um, J.; Houk, K. N.; Frontier, A. J. Tetrahedron, 2009, 65, 3165-3179. Invited article for Tetrahedron Symposium-In-Print; honoring [award winner] Justin DuBois.

Origins of Stereoselectivity in the Oxido-Alkylidenation of Alkynes
Canterbury, D. P.; Frontier, A. J.; Um, J., Cheong, P.; Goldfeld, D.; Huhn, R.; Houk, K. N. Org. Lett. 2008, 10, 4597-4600.

Polarizing the Nazarov Cyclization: The Impact of Dienone Substitution Pattern on Reactivity and Selectivity
He, W.; Meracz, I. R.; Atesin, T. A.; Caruana, P. A.; Kellenberger, C. A.; Frontier, A. J. J. Am. Chem. Soc. 2008, 130, 1003-1011.

Total Synthesis of (+)-Merrilactone A
He, W.; Huang, J.; Sun, X.; Frontier, A. J. J. Am. Chem. Soc., 2008, 130, 300-308.

Stereoselective Synthesis of Pyrrolidine Derivatives via Reduction of Substituted Pyrroles
Jiang, C.; Frontier, A. J. Org. Lett., 2007, 9, 4939-4942.

Palladium(II)- and Mercury(II)-Catalyzed Rearrangements of Propargyl Acetates
Caruana, P. A.; Frontier. A. J. Tetrahedron, 2007, 63, 10646-10656.

Development of a Nazarov Cyclization/ Wagner-Meerwein Rearrangement Sequence for the Stereoselective Synthesis of Spirocycles
Huang, J.; Frontier, A. J. J. Am. Chem. Soc., 2007, 129, 8060-8061.

Total Synthesis of (+)-Merrilactone A via Catalytic Nazarov Cyclization
He, W.; Huang, J.; Sun, X.; Frontier, A. J. J. Am. Chem. Soc., 2007, 129, 498-499.

A General Method for the Catalytic Nazarov Cyclization of Heteroaromatic Compounds
Malona, J. A.; Colbourne, J. M.; Frontier, A. J. Org. Lett., 2006, 8, 5661-5664.

Tandem Nazarov Cyclization-Michael Addition Sequence Catalyzed by an Ir(III) Complex
Janka, M..; He, W.; Haedicke, I. E.; Fronczek, F. R.; Frontier, A. J.; Eisenberg, R. J. Am. Chem. Soc., 2006, 128, 5312-5313.

The Nazarov Cyclization in Organic Synthesis. Recent Advances
Frontier, A. J.; Collison, C. Tetrahedron 2005, 61, 7577-7606. Invited Tetrahedron Report (review). This review was one of the top 25 most downloaded papers in Tetrahedron in 2006, and one of the top 50 between 2004-2007.

Preorganization in the Nazarov Cyclization: The Role of Adjacent Coordination Sites in the Highly Lewis Acidic Catalyst [IrMe(CO)(dppe)(DIB)](BAr4f)2
Janka, M.; He, W.; Frontier, A. J.; Flaschenriem, C.; Eisenberg, R. Tetrahedron 2005, 61, 6193-6206. Invited paper for Tetrahedron Symposium-In-Print; Catalysis in Industry and Academia.

Dearomatization of Furans via [2,3] - Still Wittig Rearrangement
Caruana, P. A.; Frontier. A. J. Tetrahedron, 2004, 60, 10921-10926.

Efficient Catalysis of Nazarov Cyclization Using a Cationic Iridium Complex Possessing Adjacent Labile Coordination Sites
Janka, M.; He, W.; Frontier, A. J.; Eisenberg, R. J. Am. Chem. Soc., 2004, 126, 6864-6865.

Polarizing the Nazarov Cyclization: Efficient Catalysis under Mild Conditions
He, W.; Sun, X.; Frontier, A. J. J. Am. Chem. Soc., 2003, 125, 14278-14279; addition/ correction J. Am. Chem. Soc., 2004, 126, 10493-10493.