The Oakes Lab uses high resolution quantitative microscopy and bioengineering approaches to probe mechanical interactions in cellular processes. Our research focuses on two primary aims:
- The role of mechanical interactions in regulating biological processes. We investigate how cells change their shape, adhere to each other and move.
- Material properties of protein networks. We study how the organization and architecture of protein networks influences their macroscopic material properties.
For more information, including a full list of publications, see the Oakes Lab website.
- Linsmeier I, Banerjee S, Oakes PW, Jung W, Kim T, Murrell MP. 2016. Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility. Nat Commun, 7:12615.
- Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S. 2014. Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Nat Commun, 5:5511.
- Oakes PW, Banerjee S, Marchetti CM, Gardel ML. 2014. Geometry regulates traction stresses in adherent cells. Biophys J, 107(4):825-833.
- Oakes PW, Beckham Y, Stricker J, Gardel ML. 2012. Tension is required but not sufficient for focal adhesion maturation without a stress fiber template. J Cell Biol,196(3):363-374.
- Oakes PW, Patel DC, Morin NA, Zitterbart DP, Fabry B, Reichner JS, Tang JX. 2009. Neutrophil morphology and migration are affected by substrate stiffness. Blood, 114:1387-1395.