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Patrick W. Oakes

  • Assistant Professor

PhD

420 Bausch & Lomb Hall
(585) 275-5389
poakes@rochester.edu

Office Hours: By appointment

Website


Research Overview

The Oakes Lab uses high resolution quantitative microscopy and bioengineering approaches to probe mechanical interactions in cellular processes. Our research focuses on two primary aims:

  1. The role of mechanical interactions in regulating biological processes. We investigate how cells change their shape, adhere to each other and move.
  2. Material properties of protein networks. We study how the organization and architecture of protein networks influences their macroscopic material properties.

For more information, including a full list of publications, see the Oakes Lab website.

Selected Publications

  • Linsmeier I, Banerjee S, Oakes PW, Jung W, Kim T, Murrell MP. 2016. Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility. Nat Commun, 7:12615.
  • Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S. 2014. Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Nat Commun, 5:5511.
  • Oakes PW, Banerjee S, Marchetti CM, Gardel ML. 2014. Geometry regulates traction stresses in adherent cells. Biophys J, 107(4):825-833.
  • Oakes PW, Beckham Y, Stricker J, Gardel ML. 2012. Tension is required but not sufficient for focal adhesion maturation without a stress fiber template. J Cell Biol,196(3):363-374.
  • Oakes PW, Patel DC, Morin NA, Zitterbart DP, Fabry B, Reichner JS, Tang JX. 2009. Neutrophil morphology and migration are affected by substrate stiffness. Blood, 114:1387-1395.