Athar F, Seluanov A, Gorbunova V.Cell. 2023 Mar 2;186(5):901-903. Bat crazy iPSCs. doi: 10.1016/j.cell.2023.01.033.PMID: 36868212
2022
Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Thomas DD, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. EMBO J. 2022 Nov 2;41(21):e110393. doi: 10.15252/embj.2021110393. Epub 2022 Oct 10.PMID: 36215696 PubMed Link
Fatima I, Chen G, Botchkareva NV, Sharov AA, Thornton D, Wilkinson HN, Hardman MJ, Grutzkau A, Pedro de Magalhaes J, Seluanov A, Smith ESJ, Gorbunova V, Mardaryev AN, Faulkes CG, Botchkarev VA. Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes. J Invest Dermatol. 2022 Nov;142(11):2853-2863.e4. doi: 10.1016/j.jid.2022.04.028. Epub 2022 Jun 9.PMID: 35691364 Pubmed Link
Makarova N, Kalaparthi V, Seluanov A, Gorbunova V, Dokukin ME, Sokolov I. Correlation of cell mechanics with the resistance to malignant transformation in naked mole rat fibroblasts.Nanoscale. 2022 Oct 13;14(39):14594-14602. doi: 10.1039/d2nr01633h.PMID: 36155714 PubMed Link
Emmrich S, Trapp A, Tolibzoda Zakusilo F, Straight ME, Ying AK, Tyshkovskiy A, Mariotti M, Gray S, Zhang Z, Drage MG, Takasugi M, Klusmann JH, Gladyshev VN, Seluanov A, Gorbunova V. Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits. EMBO J. 2022 Aug 1;41(15):e109694. doi: 10.15252/embj.2021109694. Epub 2022 Jun 13.PMID: 35694726 PubMed Link
Zhao Y, Simon M, Seluanov A, Gorbunova V. DNA damage and repair in age-related inflammation. Nat Rev Immunol. 2022 Jul 13. doi: 10.1038/s41577-022-00751-y. Online ahead of print.PMID: 35831609 Review. PubMed Link
Lu JY, Simon M, Zhao Y, Ablaeva J, Corson N, Choi Y, Yamada KYH, Schork NJ, Hood WR, Hill GE, Miller RA, Seluanov A, Gorbunova V. Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation. Cell Metab. 2022 Jun 7;34(6):836-856.e5. doi: 10.1016/j.cmet.2022.04.011. Epub 2022 May 16.PMID: 35580607 PubMed Link
Bettinger JQ, Simon M, Korotkov A, Welle KA, Hryhorenko JR, Seluanov A, Gorbunova V, Ghaemmaghami S. Accurate Proteomewide Measurement of Methionine Oxidation in Aging Mouse Brains. J Proteome Res. 2022 Jun 3;21(6):1495-1509. doi: 10.1021/acs.jproteome.2c00127. Epub 2022 May 18.PMID: 35584362 PubMed Link
Taylor JR, Wood JG, Mizerak E, Hinthorn S, Liu J, Finn M, Gordon S, Zingas L, Chang C, Klein MA, Denu JM, Gorbunova V, Seluanov A, Boeke JD, Sedivy JM, Helfand SL. Sirt6 regulates lifespan in Drosophila melanogaster.Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2111176119. doi: 10.1073/pnas.2111176119.PMID: 35091469 PubMed Link
Buffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño-Enríquez MA, Bronner GN, Coen C, Delaney MA, Dengler-Crish CM, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Lewis Hardell KN, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O’Connor TP, Okanoya K, O’Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos-Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, Smith ESJ. The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole-rat biology. Biol Rev Camb Philos Soc. 2022 Feb;97(1):115-140. doi: 10.1111/brv.12791. Epub 2021 Sep 3.PMID: 34476892 PubMed Link
Kerepesi C, Meer MV, Ablaeva J, Amoroso VG, Lee SG, Zhang B, Gerashchenko MV, Trapp A, Yim SH, Lu AT, Levine ME, Seluanov A, Horvath S, Park TJ, Gorbunova V, Gladyshev VN. Epigenetic aging of the demographically non-aging naked mole-rat. Nat Commun. 2022 Jan 17;13(1):355. doi: 10.1038/s41467-022-27959-9.PMID: 35039495 PubMed Link
Horvath S, Haghani A, Macoretta N, Ablaeva J, Zoller JA, Li CZ, Zhang J, Takasugi M, Zhao Y, Rydkina E, Zhang Z, Emmrich S, Raj K, Seluanov A, Faulkes CG, Gorbunova V.
DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders. Nat Aging. 2022 Jan;2(1):46-59. doi: 10.1038/s43587-021-00152-1. Epub 2021 Dec 23.PMID: 35368774 PubMed Link
2021
Chesnokova V, Zonis S, Apostolou A, Estrada HQ, Knott S, Wawrowsky K, Michelsen K, Ben-Shlomo A, Barrett R, Gorbunova V, Karalis K, Melmed S. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Cell Rep. 2021 Dec 14;37(11):110068. doi: 10.1016/j.celrep.2021.110068.PMID: 34910915 PubMed Link
Zakusilo FT, Kerry O’Banion M, Gelbard HA, Seluanov A, Gorbunova V. Matters of size: Roles of hyaluronan in CNS aging and disease. Ageing Res Rev. 2021 Dec;72:101485. doi: 10.1016/j.arr.2021.101485. Epub 2021 Oct 9.PMID: 34634492 Free PMC article. Review. PubMed Link
Korotkov A, Seluanov A, Gorbunova V. Sirtuin 6: linking longevity with genome and epigenome stability. Trends Cell Biol. 2021 Dec;31(12):994-1006. doi: 10.1016/j.tcb.2021.06.009. Epub 2021 Jul 17.PMID: 34281779 Review. PubMed Link
Zhao Y, Seluanov A, Gorbunova V. Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms. Annu Rev Genet. 2021 Aug 20. doi: 10.1146/annurev-genet-071719-021009. PubMed Link
Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, Woodham TA, Taylor JR, Helfand SL, Sedivy JM. The role of retrotransposable elements in ageing and age-associated diseases. Nature. 2021 Aug;596(7870):43-53. doi: 10.1038/s41586-021-03542-y. Epub 2021 Aug 4. PubMed Link
Korotkov A, Seluanov A, Gorbunova V. Sirtuin 6: linking longevity with genome and epigenome stability.Trends Cell Biol. 2021 Jul 17:S0962-8924(21)00125-2. doi: 10.1016/j.tcb.2021.06.009. PubMed Link
Swovick K, Firsanov D, Welle KA, Hryhorenko JR, Wise JP Sr, George C, Sformo TL, Seluanov A, Gorbunova V, Ghaemmaghami S. Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands. Mol Cell Proteomics . 2021 Jan 7;20:100041. doi: 10.1074/mcp.RA120.002301. PubMed Link
2020
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Dec 30.PMID: 33378272 Free PMC article. Review. PubMed Link
Taguchi T, Kotelsky A, Takasugi M, Chang M, Ke Z, Betancourt M, Buckley MR, Zuscik M, Seluanov A, Gorbunova V. Naked mole-rats are extremely resistant to post-traumatic osteoarthritis. Aging Cell. 2020 Nov;19(11):e13255. doi: 10.1111/acel.13255. Epub 2020 Oct 28. PubMed Link
Ke Z, Firsanov D, Spencer B, Seluanov A, Gorbunova V. Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice. NPJ Aging Mech Dis. 2020 Aug 14;6:9. doi: 10.1038/s41514-020-00047-2. eCollection 2020. PubMed Link
Gorbunova V, Takasugi M, Seluanov A. Hyaluronan goes to great length. Cell Stress. 2020 Jul 17;4(9):227-229. doi: 10.15698/cst2020.09.231. PubMed Link
Zhao J, Tian X, Zhu Y, Zhang Z, Rydkina E, Yuan Y, Zhang H, Roy B, Cornwell A, Nevo E, Shang X, Huang R, Kristiansen K, Seluanov A, Fang X, Gorbunova V. Transformation of naked mole-rat cells. Nature. 2020 Jul;583(7814):E8-E13. doi: 10.1038/s41586-020-2411-9.PMID: 32612220Free PMC article. PubMed Link
Simon M, Emmrich S, Seluanov A, Gorbunova V. A hairy tale: SIRT7 safeguards skin stem cells during aging. EMBO J. 2020 Sep 15;39(18):e106294. doi: 10.15252/embj.2020106294. Epub 2020 Aug 16.
PMID: 32803757 PubMed Link
Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V. Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Nat Commun. 2020 May 12;11(1):2376. doi: 10.1038/s41467-020-16050-w. PubMed Link
Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 Jul 28;32(4):107949. doi: 10.1016/j.celrep.2020.107949. PubMed Link
Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A, Gorbunova V. SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. Aging (Albany NY) . 2020 Jun 25;12(12):11165-11184. doi: 10.18632/aging.103567 PubMed Link
Kumar V, Agrawal R, Pandey A, Kopf S, Hoeffgen M, Kaymak S, Bandapalli OR, Gorbunova V, Seluanov A, Mall MA, Herzig S, Nawroth PP. Compromised DNA repair is responsible for diabetes-associated fibrosis. EMBO J. 2020 Jun 2;39(11):e103477. doi: 10.15252/embj.2019103477. Epub 2020 Apr 27. PubMed Link
Gorbunova V, Seluanov A, Kennedy BK. The World Goes Bats: Living Longer and Tolerating Viruses.Cell Metab. 2020 Jul 7;32(1):31-43. doi: 10.1016/j.cmet.2020.06.013.PMID: 32640245 Free PMC article. Review. PubMed link
Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V. Proteomics of Long-Lived Mammals . 2020 Mar;20(5-6):e1800416. doi: 10.1002/pmic.201800416. Epub 2020 Jan 9. PMID: 31737995 Free PMC article. Review. PubMed Link
2019
Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, Kondo A, Wadhwani NR, Lulla R, Goldman S, Venneti S, Becher OJ, Zou L, Shilatifard A, Hashizume R. Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2019 Sep 15;25(18):5572-5583. doi: 10.1158/1078-0432.CCR-18-3890. Epub 2019 Jun 21.PMID: 31227500Free PMC article. PubMed Link
Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P.Publisher Correction: Lipidome determinants of maximal lifespan in mammals. Sci Rep. 2019 May 1;9(1):6972. PubMed link
Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V. LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metab. 2019 Apr 2;29(4):871-885 PubMed link
Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 Apr 18;177(3):622-638 PubMed link
Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res. . 2019 Sep 19;47(16):8563-8580. doi: 10.1093/nar/gkz592. PubMed link
Rezazadeh S, Yang D, Tombline G, Simon M, Regan SP, Seluanov A, Gorbunova V. SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170. Nucleic Acids Res. . 2019 Sep 5;47(15):7914-7928. doi: 10.1093/nar/gkz528. PubMed link
De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. (2019). L1 drives IFN in senescent cells and promotes age-associated inflammation.Nature. 2019 Feb; 566(7742):73-78
PubMed Link
2018
Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, Imbeault M, Izsvák Z, Levin HL, Macfarlan TS, Mager DL, Feschotte C. (2018). Ten things you should know about transposable elements. Genome Biol. 2018 Nov 19;19(1):199. PubMed link
Evdokimov A, Kutuzov M, Petruseva I, Lukjanchikova N, Kashina E, Kolova E, Zemerova T, Romanenko S, Perelman P, Prokopov D, Seluanov A, Gorbunova V, Graphodatsky A, Trifonov V, Khodyreva S, Lavrik O.(2018). Naked mole rat cells display more efficient excision repair than mouse cells. Aging (Albany NY). 2018 Jun 20;10(6):1454-1473 PubMed link
Seluanov A, Gladyshev VN, Vijg J, Gorbunova V. (2018). Mechanisms of cancer resistance in long lived mammals .Nat Rev Cancer. 2018 Jul;18(7):433-441 PubMed link
Ke Z, Seluanov A, Gorbunova V. (2018) Accurate translation is important for fidelity. Aging (Albany NY). 2018 Mar 12;10(3):297-298
Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V. (2018) Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1801-1806. Pubmed link
Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V. (2018). Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). PubMed link
Swovick K, Welle KA, Hryhorenko J, Seluanov A, Gorbunova V, Ghaemmaghami S.
Mol Cell Proteomics. (2018) Cross-species comparison of proteome turnover kinetics.pii: mcp.RA117.000574. PubMed link Journal link
2017
Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V.(2017). Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. 14;9(5):1721-1734. PubMed link Journal link
Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD. (2017). AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. Oncogene. 10.1038/onc.2017.340. PubMed link Journal link
Tian X, Seluanov A, Gorbunova V. (2017). Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species. Trends Endocrinol Metab. (10):722-734. PubMed link Journal link
Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V. (2017). Translation fidelity coevolves with longevity. Aging Cell. 16(5):988-993. PubMed link Journal link
Tian X, Seluanov A, Gorbunova V. (2017) Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. Cell Metab. 2;25(5):991-992. PubMed link Journal link
Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V. (2017) Non-canonical aging model systems and why we need them. EMBO J. 13;36(8):959-963. Journal link
Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V.D., Debonneuil, E., et al. (2017). A review of the biomedical innovations for healthy longevity. Aging (Albany NY) 9, 7-25. PubMed link Journal Link
Bozek, K., Khrameeva, E.E., Reznick, J., Omerbasic, D., Bennett, N.C., Lewin, G.R., Azpurua, J., Gorbunova, V., Seluanov, A., Regnard, P., et al. (2017). Lipidome determinants of maximal lifespan in mammals. Sci Rep 7, 5. PubMed link Journal Link
2016
Gorbunova, V., Rezazadeh, S., and Seluanov, A. (2016). Dangerous Entrapment for NRF2. Cell 165, 1312-1313. PubMed link
Van Meter, M., Simon, M., Tombline, G., May, A., Morello, T.D., Hubbard, B.P., Bredbenner, K., Park, R., Sinclair, D.A., Bohr, V.A., et al. (2016). JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Rep 16, 2641-2650. PubMed link
Patrick, A., Seluanov, M., Hwang, C., Tam, J., Khan, T., Morgenstern, A., Wiener, L., Vazquez, J.M., Zafar, H., Wen, R., et al. (2016). Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY) 8, 841-847. PubMed link Journal Link
Gorbunova, V., and Seluanov, A. (2016). DNA double strand break repair, aging and the chromatin connection. Mutat Res 788, 2-6. PubMed link Journal Link
Ma, S., Upneja, A., Galecki, A., Tsai, Y.M., Burant, C.F., Raskind, S., Zhang, Q., Zhang, Z.D., Seluanov, A., Gorbunova, V., et al. (2016). Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife 5. PubMed link Journal Link
Hewitt, G., Carroll, B., Sarallah, R., Correia-Melo, C., Ogrodnik, M., Nelson, G., Otten, E.G., Manni, D., Antrobus, R., Morgan, B.A., et al. (2016). SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy 12, 1917-1930. PubMed link Journal Link
Dokukin, M., Ablaeva, Y., Kalaparthi, V., Seluanov, A., Gorbunova, V., and Sokolov, I. (2016). Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM. Biophys J 111, 236-246. PubMed link
2015
Fang, X., Nevo, E., Han, L., Levanon, E.Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., et al. (2015). Corrigendum:Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun 5, 2015 Aug 12;6:8051. doi: 10.1038/ncomms9051. PubMed link
Ma, S., Lee, S.G., Kim, E.B., Park, T.J., Seluanov, A., Gorbunova, V., Buffenstein, R., Seravalli, J., and Gladyshev, V.N. (2015). Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep 13, 1319-1326. PubMed link
MacRae, S.L., Croken, M.M., Calder, R.B., Aliper, A., Milholland, B., White, R.R., Zhavoronkov, A., Gladyshev, V.N., Seluanov, A., Gorbunova, V., et al. (2015a). DNA repair in species with extreme lifespan differences. Aging (Albany NY) 7, 1171-1184. PubMed link Journal Link
MacRae, S.L., Zhang, Q., Lemetre, C., Seim, I., Calder, R.B., Hoeijmakers, J., Suh, Y., Gladyshev, V.N., Seluanov, A., Gorbunova, V., et al. (2015b). Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell 14, 288-291. PubMed link Journal Link
Xu, Z., Zhang, L., Zhang, W., Meng, D., Zhang, H., Jiang, Y., Xu, X., Van Meter, M., Seluanov, A., Gorbunova, V., et al. (2015). SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle 14, 269-276. PubMed link Journal Link
Tian, X., Azpurua, J., Ke, Z., Augereau, A., Zhang, Z.D., Vijg, J., Gladyshev, V.N., Gorbunova, V., and Seluanov, A. (2015). INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A 112, 1053-1058. PubMed link Journal Link
2014
Vaidya, A., Mao, Z., Tian, X., Spencer, B., Seluanov, A., and Gorbunova, V. (2014). Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet 10, e1004511. PubMed link Journal Link
Van Meter, M., Gorbunova, V., and Seluanov, A. (2014a). SIRT6: a promising target for cancer prevention and therapy. Adv Exp Med Biol 818, 181-196. PubMed link Journal Link
Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A.J., Morello, T.D., Seluanov, A., and Gorbunova, V. (2014b). SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun 5, 5011. PubMed link Journal Link
Fang, X., Nevo, E., Han, L., Levanon, E.Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., et al. (2014). Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun 5, 3966. PubMed link Journal Link
Gorbunova, V., Seluanov, A., Zhang, Z., Gladyshev, V.N., and Vijg, J. (2014). Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet 15, 531-540. PubMed link Journal Link
Keane, M., Craig, T., Alfoldi, J., Berlin, A.M., Johnson, J., Seluanov, A., Gorbunova, V., Di Palma, F., Lindblad-Toh, K., Church, G.M., et al. (2014). The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics 30, 3558-3560. PubMed link Journal Link
Ke, Z., Vaidya, A., Ascher, J., Seluanov, A., and Gorbunova, V. (2014). Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups. J Am Assoc Lab Anim Sci 53, 89-91. PubMed link Journal Link
Hine, C.M., Li, H., Xie, L., Mao, Z., Seluanov, A., and Gorbunova, V. (2014). Regulation of Rad51 promoter. Cell Cycle 13, 2038-2045. PubMed link Journal Link
Cao, Y., Xu, Y., Zhang, L., Li, Z., Jiang, Y., Tian, X., Seluanov, A., Gorbunova, V., and Mao, Z. (2014). Utilization of Rad51C promoter for transcriptional targeting of cancer cells. Oncotarget 5, 1805-1811. PubMed link Journal Link
2013
Azpurua, J., Ke, Z., Chen, I.X., Zhang, Q., Ermolenko, D.N., Zhang, Z.D., Gorbunova, V., and Seluanov, A. (2013a). Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proc Natl Acad Sci U S A 110, 17350-17355. PubMed link Journal Link
Tian, X., Azpurua, J., Hine, C., Vaidya, A., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V., and Seluanov, A. (2013). High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature 499, 346-349. PubMed link Journal Link
Azpurua, J., Yang, J.N., Van Meter, M., Liu, Z., Kim, J., Lobo Ladd, A.A., Coppi, A.A., Gorbunova, V., and Seluanov, A. (2013b). IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging (Albany NY) 5, 304-314. PubMed link Journal Link
Yang, J.N., Seluanov, A., and Gorbunova, V. (2013). Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging. PLoS One 8, e73318. PubMed link Journal Link
2012
Gorbunova, V., Hine, C., Tian, X., Ablaeva, J., Gudkov, A.V., Nevo, E., and Seluanov, A. (2012). Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A 109, 19392-19396. PubMed link Journal Link
Mao, Z., Tian, X., Van Meter, M., Ke, Z., Gorbunova, V., and Seluanov, A. (2012b). Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A 109, 11800-11805. PubMed link Journal Link
Anisimov, V.N., Bartke, A., Barzilai, N., Batin, M.A., Blagosklonny, M.V., Brown-Borg, H., Budovskaya, Y., Campisi, J., Friguet, B., Fraifeld, V., et al. (2012). The second international conference “genetics of aging and longevity”. Aging (Albany NY) 4, 305-317. PubMed link Journal Link
Van Meter, M., Seluanov, A., and Gorbunova, V. (2012). Forever young? Exploring the link between rapamycin, longevity and cancer. Cell Cycle 11, 4296-4297. PubMed link Journal Link
Mao, Z., Ke, Z., Gorbunova, V., and Seluanov, A. (2012a). Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY) 4, 431-435. PubMed link Journal Link
Hine, C.M., Seluanov, A., and Gorbunova, V. (2012). Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer. Mol Ther 20, 347-355. PubMed link Journal Link
2011
Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., and Gorbunova, V. (2011). SIRT6 promotes DNA repair under stress by activating PARP1. Science 332, 1443-1446. PubMed link Journal Link
Fong, V., Osterbur, M., Capella, C., Kim, Y.E., Hine, C., Gorbunova, V., Seluanov, A., and Dewhurst, S. (2011). Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PLoS One 6, e28714. PubMed link Journal Link
Van Meter, M., Mao, Z., Gorbunova, V., and Seluanov, A. (2011a). Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY) 3, 829-835. PubMed link Journal Link
Van Meter, M., Mao, Z., Gorbunova, V., and Seluanov, A. (2011b). SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 10, 3153-3158. PubMed link Journal Link
2010
Seluanov, A., Mao, Z., and Gorbunova, V. (2010a). Analysis of DNA double-strand break (DSB) repair in mammalian cells. J Vis Exp. PubMed link Journal Link
Seluanov, A., Vaidya, A., and Gorbunova, V. (2010b). Establishing primary adult fibroblast cultures from rodents. J Vis Exp. PubMed link Journal Link
2009
Gorbunova, V., and Seluanov, A. (2009). Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev 130, 3-9. PubMed link Journal Link
Mao, Z., Jiang, Y., Liu, X., Seluanov, A., and Gorbunova, V. (2009). DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia 11, 683-691. PubMed link Journal Link
Seluanov, A., Hine, C., Azpurua, J., Feigenson, M., Bozzella, M., Mao, Z., Catania, K.C., and Gorbunova, V. (2009). Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A 106, 19352-19357. PubMed link Journal Link
2008
Seluanov, A., Hine, C., Bozzella, M., Hall, A., Sasahara, T.H., Ribeiro, A.A., Catania, K.C., Presgraves, D.C., and Gorbunova, V. (2008). Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell 7, 813-823. PubMed link Journal Link
Hine, C.M., Seluanov, A., and Gorbunova, V. (2008). Use of the Rad51 promoter for targeted anti-cancer therapy. Proc Natl Acad Sci U S A 105, 20810-20815. PubMed link Journal Link
Mao, Z., Bozzella, M., Seluanov, A., and Gorbunova, V. (2008a). Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst) 7, 1765-1771. PubMed link Journal Link
Mao, Z., Bozzella, M., Seluanov, A., and Gorbunova, V. (2008b). DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7, 2902-2906. PubMed link Journal Link
Dion, V., Lin, Y., Price, B.A., Fyffe, S.L., Seluanov, A., Gorbunova, V., and Wilson, J.H. (2008). Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair (Amst) 7, 313-320. PubMed link Journal Link
Gorbunova, V., Bozzella, M.J., and Seluanov, A. (2008). Rodents for comparative aging studies: from mice to beavers. Age (Dordr) 30, 111-119. PubMed link Journal Link
2007
Gorbunova, V., Seluanov, A., Mao, Z., and Hine, C. (2007). Changes in DNA repair during aging. Nucleic Acids Res 35, 7466-7474. PubMed link Journal Link
Mao, Z., Seluanov, A., Jiang, Y., and Gorbunova, V. (2007). TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A 104, 13068-13073. PubMed link Journal Link
Seluanov, A., Chen, Z., Hine, C., Sasahara, T.H., Ribeiro, A.A., Catania, K.C., Presgraves, D.C., and Gorbunova, V. (2007a). Telomerase activity coevolves with body mass not lifespan. Aging Cell 6, 45-52. PubMed link Journal Link
Seluanov, A., Danek, J., Hause, N., and Gorbunova, V. (2007b). Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair (Amst) 6, 1740-1748. PubMed link Journal Link
Shi, X., Seluanov, A., and Gorbunova, V. (2007). Cell divisions are required for L1 retrotransposition. Mol Cell Biol 27, 1264-1270. PubMed link Journal Link
2005
Gorbunova, V., and Seluanov, A. (2005). Making ends meet in old age: DSB repair and aging. Mech Ageing Dev 126, 621-628. PubMed link Journal Link
2004
Seluanov, A., Mittelman, D., Pereira-Smith, O.M., Wilson, J.H., and Gorbunova, V. (2004). DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci U S A 101, 7624-7629. PubMed link Journal Link
Gorbunova, V., Seluanov, A., Mittelman, D., and Wilson, J.H. (2004). Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells. Hum Mol Genet 13, 2979-2989. PubMed link Journal Link