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2024
Morandini F , Seluanov A , Gorbunova V . Slow and steady lives the longest. Nature Aging , 2024
Paine PT, Rechsteiner C , Morandini F , …, Seluanov A , Gorbunova V , Ocampo A. Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging. Frontiers in Aging , 2024.
2023
Brosh RB, Moskalev A, Gorbunova V . DNA repair and interventions in aging. Frontiers in Aging , 2023.
Zhao Y , Zheng Z , Zhang Z , Xu Y, Hillpot E , Lin YS, Zakusilo FT , Lu JY , Ablaeva J , Biashad SA , Miller RA, Nevo E, Seluanov A , Gorbunova V . Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle. Nature Communications , 2023.
Romanenko SA, …, Seluanov A , Gorbunova V , Azpurua J, Pereira JC, Ferguson-Smith MA, Graphodatsky AS. Integration of fluorescence in situ hybridization and chromosome-length genome assemblies revealed synteny map for guinea pig, naked mole-rat, and human. Scientific Reports , 2023.
Brochard T, McIntyre RL, Houtkooper RH, Seluanov A , Gorbunova V , Janssens GE. Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging. Ageing Research Reviews , 2023.
Takasugi M , Ohtani N, Takemura K, Emmrich S , Zakusilo FT , …, Seluanov A , Gorbunova V . CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance. Cell Reports , 2023.
Zhang Z , Tian X , Lu JY , Boit K , Ablaeva J , Zakusilo FT , Emmrich S , Firsanov D , Rydkina E , Biashad SA , Lu Q , Tyshkovskiy A, Gladyshev VN, Horvath S, Seluanov A , Gorbunova V . Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice. Nature , 2023.
Haghani A, …, Ablaeva J , …, Emmrich S , …, Macoretta N , …, Rydkina E , …, Takasugi M , …, Zhang Z , Zhao Y , …, Seluanov A , Gorbunova V , …, Horvath S. DNA methylation networks underlying mammalian traits. Science , 2023
Lu AT, …, Ablaeva J , …, Emmrich S , …, Gorbunova V , …, Macoretta N , …, Rydkina E , …, Seluanov A , …, Takasugi M , …, Zhang Z , …, Zhao Y , …, Horvath S. Universal DNA methylation age across mammalian tissues. Nature Aging , 2023.
Tyshkovskiy A, …, Seluanov A , Schork NJ, Gorbunova V , Dmitriev SE, Miller RA, Gladyshev VN. Distinct longevity mechanisms across and within species and their association with aging. Cell , 2023.
Vijg J, …, Gorbunova V , …, Walsh K. Mitigating age-related somatic mutation burden . Trends in Molecular Medicine , 2023
Frohlich J, …, Gorbunova V , Vinciguerra M. Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids . Geroscience , 2023.
Athar F , Seluanov A , Gorbunova V . Bat crazy iPSCs. Cell, 2023.
Zhao Y , Simon M , Seluanov A , Gorbunova V . DNA damage and repair in age-related inflammation . Nature Reviews Immunology , 2023.
Gorbunova V , Seluanov A . Introduction: Progression of the Science of Ageing . Biochemistry and Cell Biology of Ageing: Part III Biomedical Science, 2023.
2022
Simon M , Yang J, Gigas J , Earley EJ, Hillpot E , Zhang L, Zagorulya M, Tombline G , Gilbert M, Yuen SL, Pope A, Van Meter M , Emmrich S , Firsanov D , Athreya A, Biashad SA , …, Seluanov A , Suh Y, Gorbunova V . A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO Journal , 2022.
Fatima I, …, Seluanov A , Smith ESJ, Gorbunova V , …, Botchkarev VA. Skin aging in long-lived naked mole-rats is accompanied by increased expression of longevity-associated and tumor suppressor genes. Journal of Investigative Dermatology , 2022
Emmrich S , Trapp A , Tolibzoba Zakusilo F , …, Zhang Z, Drage MG, Takasugi M , …, Seluanov A , Gorbunova V . Characterization of naked mole‐rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits. The EMBO Journal , 2022.
Lu JY , Simon M , Zhao Y , Ablaeva J , Corson N , …, Seluanov A , Gorbunova V . Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation. Cell Metabolism , 2022.
Bettinger JQ, Simon M , Korotkov A , …, Seluanov A , Gorbunova V , Ghaemmaghami S. Accurate proteomewide measurement of methionine oxidation in aging mouse brains. Journal of Proteome Research , 2022.
Taylor JR, …, Gorbunova V , Seluanov A , …, Helfand SL. Sirt6 regulates lifespan in Drosophila melanogaster. Proceedings of the National Academy of Sciences , 2022.
Buffenstein R, …, Azpurua J , …, Gorbunova V , Hine C , …, Seluanov A , …, Tian X , …, Smith ESJ. The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology. Biological Reviews, 2022.
Kerepesi C, Meer MV, Ablaeva J , …, Seluanov A , …, Gorbunova V , Gladyshev VN. Epigenetic aging of the demographically non-aging naked mole-rat. Nature Communications , 2022.
Makarova N, Kalaparthi V, Seluanov A , Gorbunova V , Dokukin ME, Sokolov I. Correlation of cell mechanics with the resistance to malignant transformation in naked mole rat fibroblasts . Nanoscale , 2022.
Horvath S, Haghani A, Macoretta N , Ablaeva J , …, Takasugi M , Zhao Y , Rydkina E , Zhang Z , Emmrich S , Raj K, Seluanov A , Faulkes CG, Gorbunova V . DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders . Nature Aging , 2022.
2021
Chesnokova V, …, Gorbunova V , Karalis K, Melmed S. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Cell Reports , 2021.
Zakusilo FT , …, Seluanov A , Gorbunova V . Matters of size: Roles of hyaluronan in CNS aging and disease. Ageing Research Reviews , 2021.
Korotkov A , Seluanov A , Gorbunova V . Sirtuin 6: linking longevity with genome and epigenome stability. Trends in Cell Biology , 2021.
Zhao Y, Seluanov A , Gorbunova V . Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms. Annual Review of Genetics , 2021.
Lu JY, Seluanov A, Gorbunova V. Long-lived fish in a big pond . Science , 2021.
Zhang Q, Tombline G , Ablaeva J , …, Zhao Y , …, Seluanov A , Gladyshev VN, Gorbunova V , Zhang ZD. Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation . Cell Reports , 2021
Zhang L, Dong X, Tian X , Lee M, Ablaeva J , Firsanov D , …, Seluanov A , Gorbunova V , Vijg J. Maintenance of genome sequence integrity in long-and short-lived rodent species . Science Advances , 2021
Zhao Y , …, Zheng Z , Lu JY , Lee J, Ke Z , Ablaeva J , …, Seluanov A , Gorbunova V . Transposon-triggered innate immune response confers cancer resistance to the blind mole rat . Nature Immunology , 2021.
Emmrich S , Zakusilo FT , Trapp A , …, Seluanov A , Gorbunova V . Ectopic cervical thymi and no thymic involution until midlife in naked mole rats. Aging Cell , 2021.
Lin J, …, Gorbunova V , …, Zhang ZD. Rare genetic coding variants associated with human longevity and protection against age-related diseases. Nature Aging , 2021.
Gorbunova V , Seluanov A , …, Sedivy JM. The role of retrotransposable elements in ageing and age-associated diseases. Nature , 2021.
Morevati M, …, Gorbunova V , Olgaard K, Lewin E. Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat. Scientific Reports , 2021.
Kacprzyk J, …, Gorbunova V , …, Teeling EC. Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals. Aging (Albany NY) , 2021.
Augereau A, …, Gorbunova V , Gilson E, Gladyshev VN. Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Science Advances , 2021.
Swovick K, Firsanov D , …, Seluanov A , Gorbunova V , Ghaemmaghami S. Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands. Molecular & Cellular Proteomics , 2021.
2020
Mkrtchyan GV, …, Gorbunova V , …, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY), 2020.
Pawelec G, …, Gorbunova V, …, Seluanov A, …, Cohen AA. The conundrum of human immune system “senescence” . Mechanisms of Ageing and Development , 2020
Taguchi T , Kotelsky A, Takasugi M , Chang M, Ke Z , Betancourt M , …, Seluanov A , Gorbunova V . Naked mole-rats are extremely resistant to post-traumatic osteoarthritis. Aging Cell , 2020.
Cohen AA, …, Gorbunova V , …, Fülöp T. Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development , 2020.
Simon M , Emmrich S , Seluanov A , Gorbunova V . A hairy tale: SIRT7 safeguards skin stem cells during aging. The EMBO Journal , 2020.
Gorbunova V , Takasugi M , Seluanov A . Hyaluronan goes to great length. Cell Stress , 2020
Ke Z , Firsanov D , Spencer B , Seluanov A , Gorbunova V . Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice. NPJ Aging and Mechanisms of Disease , 2020.
Zhang ZD, …, Gorbunova V , …, Vijg J. Genetics of extreme human longevity to guide drug discovery for healthy ageing . Nature Metabolism , 2020
Zhou X, …, Tian X , …, Seluanov A , Zhang ZD, Gorbunova V , Liu X, Gladyshev VN. Beaver and naked mole rat genomes reveal common paths to longevity. Cell Reports , 2020
Gorbunova V , Seluanov A , Kennedy BK. The World Goes Bats: Living Longer and Tolerating Viruses. Cell Metabolism , 2020.
Rezazadeh S , Yang D , Biashad SA , Firsanov D , Takasugi M , Gilbert M, Tombline G , Bhanu NV, Garcia BA, Seluanov A , Gorbunova V . SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. Aging (Albany NY) , 2020
Kumar V, …, Gorbunova V , Seluanov A , …, Nawroth PP. Compromised DNA repair is responsible for diabetes-associated fibrosis. The EMBO Journal , 2020.
Takasugi M , Firsanov D , Tombline G , Ning H, Ablaeva J , Seluanov A , Gorbunova V . Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Nature Communications , 2020.
Tombline G , Gigas J , Macoretta N , Zacher M , Emmrich S , Zhao Y , Seluanov A , Gorbunova V . Proteomics of Long-Lived Mammals. Proteomics , 2020.
Zhao J, Tian X , Zhu Y, Zhang Z , Rydkina E , …, Cornwell A , …, Seluanov A , Fang X, Gorbunova V . Reply to: Transformation of naked mole-rat cells. Nature , 2020.
2019
Chen Y, Zhang H, Xu Z, …, Tian X , Seluanov A , …, Gorbunova V , Mao Z. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Research, 2019.
Katagi H, …, Tian X , Seluanov A , Gorbunova V , …, Hashizume R. Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. Clinical Cancer Research , 2019.
Rezazadeh S , Yang D , Tombline G , Simon M , Regan SP , Seluanov A , Gorbunova V . SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170. Nucleic Acids Research , 2019.
Tian X , Firsanov D , Zhang Z , Cheng Y, Luo L , Tombline G , Tan R , Simon M , Henderson S , Steffan J , Goldfarb A , Tam J , Zheng K , Cornwell A , Johnson A , …, Seluanov A , Gorbunova V . SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell , 2019.
Simon M , Van Meter M , Ablaeva J , Ke Z, Gonzalez RS, Taguchi T , …, Seluanov A , Gorbunova V . LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metabolism , 2019.
Núñez FJ, …, Gorbunova V , …, Castro MG. IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response. Science Translational Medicine , 2019.
De Cecco M, …, Simon M , Seluanov A , Gorbunova V , …, Sedivy JM. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature, 2019.
Chesnokova V, …, Gorbunova V , Melmed S. Excess growth hormone suppresses DNA damage repair in epithelial cells. JCI Insight , 2019
2018
Bourque G, …, Gorbunova V , Seluanov A , …, Feschotte C. Ten things you should know about transposable elements. Genome Biology , 2018.
Seluanov A , Gladyshev VN, Vijg J, Gorbunova V . Mechanisms of cancer resistance in long lived mammals. Nature Reviews Cancer , 2018.
Evdokimov A, …, Seluanov A , Gorbunova V , …, Lavrik O. Naked mole rat cells display more efficient excision repair than mouse cells. Aging (Albany NY) , 2018.
Swovick K, Welle KA, Hryhorenko J, Seluanov A , Gorbunova V , Ghaemmaghami S.
Cross-species comparison of proteome turnover kinetics. Molecular & Cellular Proteomics , 2018.
Tian X , Doerig K , Park R , Can Ran Qin A , Hwang C , Neary A , Gilbert M , Seluanov A , Gorbunova V . Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philosophical Transactions of the Royal Society B: Biological Sciences , 2018
Ke Z , Seluanov A , Gorbunova V . Accurate translation is important for fidelity. Aging (Albany NY) , 2018.
Ghosh S, …, Gorbunova V , Liu X, Zhou Z. Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. eLife , 2018.
Zhao Y , …, Tian X , …, Seluanov A , Gorbunova V . Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proceedings of the National Academy of Sciences , 2018.
D Piscitello, …, V Gorbunova , A Seluanov , DA Gillespie, PD Adams. AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. Oncogene , 2018.
2017
Tan L , Ke Z , Tombline G , Macoretta N , Hayes K , Tian X , Lv R, Ablaeva J , Gilbert M , …, Seluanov A , Gorbunova V . Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports , 2017.
Tian X , Seluanov A , Gorbunova V . Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species. Trends in Endocrinology & Metabolism , 2017.
Ke Z , …, Seluanov A , Gorbunova V . Translation fidelity coevolves with longevity. Aging Cell , 2017.
Nieborowska-Skorska M, …, Gorbunova V , …, Skorski T. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. The Journal of Clinical Investigation , 2017.
Yang C, …, Gorbunova V, …, Paschal BM. Ubiquitin modification by the E3 ligase/ADP-ribosyltransferase Dtx3L/Parp9. Molecular Cell , 2017.
Tian X , Seluanov A , Gorbunova V . Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. Cell Metabolism , 2017.
Valenzano DR, Aboobaker A, Seluanov A , Gorbunova V . Non-canonical aging model systems and why we need them. The EMBO Journal , 2017.
Li J, …, Gorbunova V , …, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science , 2017.
Bozek K, …, Azpurua J , Gorbunova V , Seluanov A , …, Philipp Khaitovich. Lipidome determinants of maximal lifespan in mammals. Scientific Reports , 2017.
Moskalev A, …, Gorbunova V , …, Seluanov A , …, Zhavoronkov A. A review of the biomedical innovations for healthy longevity. Aging (Albany NY) , 2017.
2016
Ma S, …, Seluanov A, Gorbunova V , …, Gladyshev VN. Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife , 2016.
Hewitt G, Carroll B, Rezazadeh S , …, Seluanov A , Gorbunova V , …, Korolchuk VI. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy , 2016.
Van Meter M , Simon M , Tombline G , May A, Morello TD , Hubbard BP, Bredbenner K , Park R , …, Gorbunova V , Seluanov A . JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports , 2016.
Dokukin M, Ablaeva J , Kalaparthi V, Seluanov A , Gorbunova V , Sokolov I. Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM. Biophysical Journal , 2016.
Gorbunova V , Rezazadeh S , Seluanov A . Dangerous Entrapment for NRF2. Cell , 2016.
Gorbunova V , Seluanov A . DNA double strand break repair, aging and the chromatin connection. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis , 2016.
Patrick A , Seluanov M , Hwang C , Tam J , Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S , …, Tian X , Ablaeva J , …, Seluanov A, Gorbunova V . Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY) , 2016.
Koschmann C, …, Gorbunova V , …, Castro MG. ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. Science Translational Medicine , 2016.
Van Meter M , Gorbunova V , Seluanov A . Comparative biology of aging: insights from long-lived rodent species. Handbook of the Biology of Aging , 2016.
2015
Brohus M, Gorbunova V , …, Conover CA. The insulin-like growth factor system in the long-lived naked mole-rat. PLoS One , 2015
MacRae SL, …, Seluanov A , Gorbunova V , Zhang ZD, Vijg J. DNA repair in species with extreme lifespan differences. Aging (Albany NY) , 2015.
Ma S, …, Seluanov A , Gorbunova V , …, Gladyshev VN. Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Reports , 2015.
Fang X, …, Gorbunova V , …, Seluanov A, Azpurua J , …, Jun Wang. Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nature Communications , 2015.
MacRae SL, …, Seluanov A , Gorbunova V , Vijg J, Zhang ZD. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell , 2015.
Tian X , Azpurua J , Ke Z , …, Gorbunova V , Seluanov A . (2015). INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proceedings of the National Academy of Sciences , 2015.
Xu Z, …, Van Meter M , Seluanov A , Gorbunova V , Mao Z. SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle , 2015.
2014
Keane M, …, Seluanov A , Gorbunova V , …, de Magalhães JP. The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics , 2014.
Gorbunova V , Boeke JD, Helfand SL, Sedivy JM. Sleeping dogs of the genome. Science , 2014.
Van Meter M , Kashyap M , Rezazadeh S , Geneva AJ , Morello TD , Seluanov A , Gorbunova V . SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nature Communications , 2014.
Gorbunova V , Seluanov A , Zhang Z, Gladyshev VN, Vijg J. Comparative genetics of longevity and cancer: insights from long-lived rodents. Nature Reviews Genetics , 2014.
Vaidya A , Mao Z , Tian X , Spencer B , Seluanov A , Gorbunova V . Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genetics , 2014.
Hine CM , Li H , Xie L , Mao Z , Seluanov A , Gorbunova V . Regulation of Rad51 promoter. Cell Cycle , 2014.
Fang X, …, Gorbunova V , …, Seluanov A , Azpurua J , …, Wang J. Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nature Communications , 2014.
Cao Y, …, Tian X , Seluanov A , Gorbunova V , Mao Z. Utilization of Rad51C promoter for transcriptional targeting of cancer cells. Oncotarget , 2014.
Van Meter M , Gorbunova V , Seluanov A . SIRT6: a promising target for cancer prevention and therapy . Anticancer Genes , 2014.
Ke Z , Vaidya A , Ascher J, Seluanov A , Gorbunova V . Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups. Journal of the American Association for Laboratory Animal Science , 2014.
2013
Yao H, Sundar IK, Gorbunova V , Rahman I. P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence. PLoS One , 2013.
Azpurua J , Ke Z , Chen IX , Zhang Q, Ermolenko DN , Zhang ZD, Gorbunova V , Seluanov A . Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proceedings of the National Academy of Sciences , 2013.
Yang JN , Seluanov A , Gorbunova V . Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging. PLoS One , 2013.
Tilgner K, …, Gorbunova V , …, Lako M. Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors. Stem Cells , 2013.
Tilgner K, …, Gorbunova V , …, Lako M. A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors. Cell Death & Differentiation , 2013.
Tian X , Azpurua J , Hine C , Vaidya A , Myakishev-Rempel M , Ablaeva J , Mao Z , Nevo E, Gorbunova V , Seluanov A . High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature , 2013.
Azpurua J , Yang JN , Van Meter M , Liu Z , Kim J , Lobo Ladd AA, Coppi AA, Gorbunova V , Seluanov A . IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging (Albany NY) , 2013.
Leu J, …, Gorbunova V , Lee Y. Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity. International journal of radiation biology , 2013.
2012
Van Meter M , Seluanov A , Gorbunova V . Forever young? Exploring the link between rapamycin, longevity and cancer. Cell Cycle , 2012.
Gorbunova V , Hine C , Tian X , Ablaeva J , Gudkov AV, Nevo E, Seluanov A . Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proceedings of the National Academy of Sciences , 2012.
Mao Z , Tian X , Van Meter M , Ke Z , Gorbunova V , Seluanov A . Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proceedings of the National Academy of Sciences , 2012.
Mao Z , Ke Z , Gorbunova V , Seluanov A . Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY) , 2012.
Anisimov VN, …, Gorbunova V , …, Seluanov A , …, Zimniak P. The second international conference “genetics of aging and longevity”. Aging (Albany NY) , 2012.
Rahman I, Kinnula VL, Gorbunova V , Yao H. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Preventive medicine , 2012.
Hine CM , Seluanov A , Gorbunova V . Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer. Molecular Therapy , 2012.
2011
Fong V, …, Hine C , Gorbunova V , Seluanov A , Dewhurst S. Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PLoS One , 2011.
Van Meter M , Mao Z , Gorbunova V , Seluanov A . SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle , 2011.
Van Meter M , Mao Z , Gorbunova V , Seluanov A . Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY) , 2011.
Mao Z , Hine C , Tian X , Van Meter M , Au M , Vaidya A , Seluanov A , Gorbunova V . SIRT6 promotes DNA repair under stress by activating PARP1. Science , 2011.
2010
2009
Seluanov A , Hine C , Azpurua J , Feigenson M , Bozzella M , Mao Z , Catania KC, Gorbunova V . Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proceedings of the National Academy of Sciences , 2009.
Mao Z , Jiang Y , Liu X , Seluanov A , Gorbunova V . DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia , 2009.
Gorbunova V , Seluanov A . Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mechanisms of ageing and development , 2009.
2008
Hine CM , Seluanov A , Gorbunova V . Use of the Rad51 promoter for targeted anti-cancer therapy. Proceedings of the National Academy of Sciences , 2008.
Seluanov A , Hine CM , Bozzella M , …, Gorbunova V . Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell, 2008.
Mao Z , Bozzella M , Seluanov A , Gorbunova V . Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair , 2008.
Mao Z , Bozzella M , Seluanov A , Gorbunova V . DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle , 2008.
Gorbunova V , Bozzella MJ , Seluanov A . Rodents for comparative aging studies: from mice to beavers. Age , 2008.
Dion V, …, Seluanov A , Gorbunova V , Wilson JH. Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair , 2008.
2007
Seluanov A , Danek J , Hause N , Gorbunova V . Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair , 2007.
Gorbunova V , Seluanov A , Mao Z , Hine CM . Changes in DNA repair during aging. Nucleic Acids Research , 2007.
Mao Z , Seluanov A , Jiang Y , Gorbunova V . TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proceedings of the National Academy of Sciences , 2007.
Seluanov A , Chen Z, Hine CM , …, Gorbunova V . Telomerase activity coevolves with body mass not lifespan. Aging Cell , 2007.
Shi X , Seluanov A , Gorbunova V . Cell divisions are required for L1 retrotransposition. Molecular and cellular biology , 2007.
2005
2004