Publications

Published by Gorbunova & Seluanov Labs

2018

  • Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V. (2018). Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741).
    PubMed link
  • Swovick K, Welle KA, Hryhorenko J, Seluanov A, Gorbunova V, Ghaemmaghami S.
    Mol Cell Proteomics. (2018) Cross-species comparison of proteome turnover kinetics.pii: mcp.RA117.000574.
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2017

  • Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V.(2017). Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. 14;9(5):1721-1734.
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  • Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD. (2017). AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. Oncogene. 10.1038/onc.2017.340.
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  • Tian X, Seluanov A, Gorbunova V. (2017). Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species. Trends Endocrinol Metab. (10):722-734.
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  • Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V. (2017). Translation fidelity coevolves with longevity. Aging Cell. 16(5):988-993.
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  • Tian X, Seluanov A, Gorbunova V. (2017) Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. Cell Metab. 2;25(5):991-992.
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  • Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V. (2017) Non-canonical aging model systems and why we need them. EMBO J. 13;36(8):959-963.
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  • Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V.D., Debonneuil, E., et al. (2017). A review of the biomedical innovations for healthy longevity. Aging (Albany NY) 9, 7-25.
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  • Bozek, K., Khrameeva, E.E., Reznick, J., Omerbasic, D., Bennett, N.C., Lewin, G.R., Azpurua, J., Gorbunova, V., Seluanov, A., Regnard, P., et al. (2017). Lipidome determinants of maximal lifespan in mammals. Sci Rep 7, 5.
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2016

  • Gorbunova, V., Rezazadeh, S., and Seluanov, A. (2016). Dangerous Entrapment for NRF2. Cell 165, 1312-1313.
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  • Van Meter, M., Simon, M., Tombline, G., May, A., Morello, T.D., Hubbard, B.P., Bredbenner, K., Park, R., Sinclair, D.A., Bohr, V.A., et al. (2016). JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Rep 16, 2641-2650.
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  • Patrick, A., Seluanov, M., Hwang, C., Tam, J., Khan, T., Morgenstern, A., Wiener, L., Vazquez, J.M., Zafar, H., Wen, R., et al. (2016). Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY) 8, 841-847.
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  • Gorbunova, V., and Seluanov, A. (2016). DNA double strand break repair, aging and the chromatin connection. Mutat Res 788, 2-6.
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  • Ma, S., Upneja, A., Galecki, A., Tsai, Y.M., Burant, C.F., Raskind, S., Zhang, Q., Zhang, Z.D., Seluanov, A., Gorbunova, V., et al. (2016). Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife 5.
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  • Hewitt, G., Carroll, B., Sarallah, R., Correia-Melo, C., Ogrodnik, M., Nelson, G., Otten, E.G., Manni, D., Antrobus, R., Morgan, B.A., et al. (2016). SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy 12, 1917-1930.
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  • Dokukin, M., Ablaeva, Y., Kalaparthi, V., Seluanov, A., Gorbunova, V., and Sokolov, I. (2016). Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM. Biophys J 111, 236-246.
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2015

  • Fang, X., Nevo, E., Han, L., Levanon, E.Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., et al. (2015). Corrigendum:Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun 5, 2015 Aug 12;6:8051. doi: 10.1038/ncomms9051.
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  • Ma, S., Lee, S.G., Kim, E.B., Park, T.J., Seluanov, A., Gorbunova, V., Buffenstein, R., Seravalli, J., and Gladyshev, V.N. (2015). Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep 13, 1319-1326.
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  • MacRae, S.L., Croken, M.M., Calder, R.B., Aliper, A., Milholland, B., White, R.R., Zhavoronkov, A., Gladyshev, V.N., Seluanov, A., Gorbunova, V., et al. (2015a). DNA repair in species with extreme lifespan differences. Aging (Albany NY) 7, 1171-1184.
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  • MacRae, S.L., Zhang, Q., Lemetre, C., Seim, I., Calder, R.B., Hoeijmakers, J., Suh, Y., Gladyshev, V.N., Seluanov, A., Gorbunova, V., et al. (2015b). Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell 14, 288-291.
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  • Xu, Z., Zhang, L., Zhang, W., Meng, D., Zhang, H., Jiang, Y., Xu, X., Van Meter, M., Seluanov, A., Gorbunova, V., et al. (2015). SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle 14, 269-276.
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  • Tian, X., Azpurua, J., Ke, Z., Augereau, A., Zhang, Z.D., Vijg, J., Gladyshev, V.N., Gorbunova, V., and Seluanov, A. (2015). INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A 112, 1053-1058.
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2014

  • Vaidya, A., Mao, Z., Tian, X., Spencer, B., Seluanov, A., and Gorbunova, V. (2014). Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet 10, e1004511.
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  • Van Meter, M., Gorbunova, V., and Seluanov, A. (2014a). SIRT6: a promising target for cancer prevention and therapy. Adv Exp Med Biol 818, 181-196.
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  • Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A.J., Morello, T.D., Seluanov, A., and Gorbunova, V. (2014b). SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun 5, 5011.
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  • Fang, X., Nevo, E., Han, L., Levanon, E.Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., et al. (2014). Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun 5, 3966.
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  • Gorbunova, V., Seluanov, A., Zhang, Z., Gladyshev, V.N., and Vijg, J. (2014). Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet 15, 531-540.
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  • Keane, M., Craig, T., Alfoldi, J., Berlin, A.M., Johnson, J., Seluanov, A., Gorbunova, V., Di Palma, F., Lindblad-Toh, K., Church, G.M., et al. (2014). The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics 30, 3558-3560.
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  • Ke, Z., Vaidya, A., Ascher, J., Seluanov, A., and Gorbunova, V. (2014). Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups. J Am Assoc Lab Anim Sci 53, 89-91.
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  • Hine, C.M., Li, H., Xie, L., Mao, Z., Seluanov, A., and Gorbunova, V. (2014). Regulation of Rad51 promoter. Cell Cycle 13, 2038-2045.
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  • Cao, Y., Xu, Y., Zhang, L., Li, Z., Jiang, Y., Tian, X., Seluanov, A., Gorbunova, V., and Mao, Z. (2014). Utilization of Rad51C promoter for transcriptional targeting of cancer cells. Oncotarget 5, 1805-1811.
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2013

  • Azpurua, J., Ke, Z., Chen, I.X., Zhang, Q., Ermolenko, D.N., Zhang, Z.D., Gorbunova, V., and Seluanov, A. (2013a). Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proc Natl Acad Sci U S A 110, 17350-17355.
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  • Tian, X., Azpurua, J., Hine, C., Vaidya, A., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V., and Seluanov, A. (2013). High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature 499, 346-349.
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  • Azpurua, J., Yang, J.N., Van Meter, M., Liu, Z., Kim, J., Lobo Ladd, A.A., Coppi, A.A., Gorbunova, V., and Seluanov, A. (2013b). IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging (Albany NY) 5, 304-314.
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  • Yang, J.N., Seluanov, A., and Gorbunova, V. (2013). Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging. PLoS One 8, e73318.
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2012

  • Gorbunova, V., Hine, C., Tian, X., Ablaeva, J., Gudkov, A.V., Nevo, E., and Seluanov, A. (2012). Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A 109, 19392-19396.
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  • Mao, Z., Tian, X., Van Meter, M., Ke, Z., Gorbunova, V., and Seluanov, A. (2012b). Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A 109, 11800-11805.
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  • Anisimov, V.N., Bartke, A., Barzilai, N., Batin, M.A., Blagosklonny, M.V., Brown-Borg, H., Budovskaya, Y., Campisi, J., Friguet, B., Fraifeld, V., et al. (2012). The second international conference “genetics of aging and longevity”. Aging (Albany NY) 4, 305-317.
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  • Van Meter, M., Seluanov, A., and Gorbunova, V. (2012). Forever young? Exploring the link between rapamycin, longevity and cancer. Cell Cycle 11, 4296-4297.
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  • Mao, Z., Ke, Z., Gorbunova, V., and Seluanov, A. (2012a). Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY) 4, 431-435.
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  • Hine, C.M., Seluanov, A., and Gorbunova, V. (2012). Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer. Mol Ther 20, 347-355.
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2011

  • Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., and Gorbunova, V. (2011). SIRT6 promotes DNA repair under stress by activating PARP1. Science 332, 1443-1446.
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  • Fong, V., Osterbur, M., Capella, C., Kim, Y.E., Hine, C., Gorbunova, V., Seluanov, A., and Dewhurst, S. (2011). Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PLoS One 6, e28714.
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  • Van Meter, M., Mao, Z., Gorbunova, V., and Seluanov, A. (2011a). Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY) 3, 829-835.
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  • Van Meter, M., Mao, Z., Gorbunova, V., and Seluanov, A. (2011b). SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 10, 3153-3158.
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2010

  • Seluanov, A., Mao, Z., and Gorbunova, V. (2010a). Analysis of DNA double-strand break (DSB) repair in mammalian cells. J Vis Exp.
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  • Seluanov, A., Vaidya, A., and Gorbunova, V. (2010b). Establishing primary adult fibroblast cultures from rodents. J Vis Exp.
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2009

  • Gorbunova, V., and Seluanov, A. (2009). Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev 130, 3-9.
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  • Mao, Z., Jiang, Y., Liu, X., Seluanov, A., and Gorbunova, V. (2009). DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia 11, 683-691.
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  • Seluanov, A., Hine, C., Azpurua, J., Feigenson, M., Bozzella, M., Mao, Z., Catania, K.C., and Gorbunova, V. (2009). Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A 106, 19352-19357.
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2008

  • Seluanov, A., Hine, C., Bozzella, M., Hall, A., Sasahara, T.H., Ribeiro, A.A., Catania, K.C., Presgraves, D.C., and Gorbunova, V. (2008). Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell 7, 813-823.
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  • Hine, C.M., Seluanov, A., and Gorbunova, V. (2008). Use of the Rad51 promoter for targeted anti-cancer therapy. Proc Natl Acad Sci U S A 105, 20810-20815.
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  • Mao, Z., Bozzella, M., Seluanov, A., and Gorbunova, V. (2008a). Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst) 7, 1765-1771.
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  • Mao, Z., Bozzella, M., Seluanov, A., and Gorbunova, V. (2008b). DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7, 2902-2906.
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  • Dion, V., Lin, Y., Price, B.A., Fyffe, S.L., Seluanov, A., Gorbunova, V., and Wilson, J.H. (2008). Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair (Amst) 7, 313-320.
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  • Gorbunova, V., Bozzella, M.J., and Seluanov, A. (2008). Rodents for comparative aging studies: from mice to beavers. Age (Dordr) 30, 111-119.
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2007

  • Gorbunova, V., Seluanov, A., Mao, Z., and Hine, C. (2007). Changes in DNA repair during aging. Nucleic Acids Res 35, 7466-7474.
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  • Mao, Z., Seluanov, A., Jiang, Y., and Gorbunova, V. (2007). TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A 104, 13068-13073.
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  • Seluanov, A., Chen, Z., Hine, C., Sasahara, T.H., Ribeiro, A.A., Catania, K.C., Presgraves, D.C., and Gorbunova, V. (2007a). Telomerase activity coevolves with body mass not lifespan. Aging Cell 6, 45-52.
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  • Seluanov, A., Danek, J., Hause, N., and Gorbunova, V. (2007b). Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair (Amst) 6, 1740-1748.
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  • Shi, X., Seluanov, A., and Gorbunova, V. (2007). Cell divisions are required for L1 retrotransposition. Mol Cell Biol 27, 1264-1270.
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2005

  • Gorbunova, V., and Seluanov, A. (2005). Making ends meet in old age: DSB repair and aging. Mech Ageing Dev 126, 621-628.
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2004

  • Seluanov, A., Mittelman, D., Pereira-Smith, O.M., Wilson, J.H., and Gorbunova, V. (2004). DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci U S A 101, 7624-7629.
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  • Gorbunova, V., Seluanov, A., Mittelman, D., and Wilson, J.H. (2004). Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells. Hum Mol Genet 13, 2979-2989.
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