Publications

Published by Gorbunova & Seluanov Labs

2021

  • Zhao Y, Seluanov A, Gorbunova V. Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms. Annu Rev Genet.  2021 Aug 20. doi: 10.1146/annurev-genet-071719-021009.                                                              PubMed Link
  • Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, Woodham TA, Taylor JR, Helfand SL, Sedivy JM.  The role of retrotransposable elements in ageing and age-associated diseases. Nature. 2021 Aug;596(7870):43-53. doi: 10.1038/s41586-021-03542-y. Epub 2021 Aug 4. PubMed Link
  • Korotkov A, Seluanov A, Gorbunova V. Sirtuin 6: linking longevity with genome and epigenome stability.Trends Cell Biol. 2021 Jul 17:S0962-8924(21)00125-2. doi: 10.1016/j.tcb.2021.06.009.                                                                                  PubMed Link
  • Swovick K, Firsanov D, Welle KA, Hryhorenko JR, Wise JP Sr, George C, Sformo TL, Seluanov A, Gorbunova V, Ghaemmaghami S. Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands. Mol Cell Proteomics . 2021 Jan 7;20:100041. doi: 10.1074/mcp.RA120.002301. PubMed Link

2020

  • Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M.  ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454.  Dec 30.PMID: 33378272 Free PMC article. Review.  PubMed Link
  • Taguchi T, Kotelsky A, Takasugi M, Chang M, Ke Z, Betancourt M, Buckley MR, Zuscik M, Seluanov A, Gorbunova V. Naked mole-rats are extremely resistant to post-traumatic osteoarthritis. Aging Cell. 2020 Nov;19(11):e13255. doi: 10.1111/acel.13255. Epub 2020 Oct 28. PubMed Link
  • Ke Z, Firsanov D, Spencer B, Seluanov A, Gorbunova V. Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice. NPJ Aging Mech Dis.  2020 Aug 14;6:9. doi: 10.1038/s41514-020-00047-2. eCollection 2020. PubMed Link
  • Gorbunova V, Takasugi M, Seluanov A. Hyaluronan goes to great length. Cell Stress. 2020 Jul 17;4(9):227-229. doi: 10.15698/cst2020.09.231. PubMed Link
  • Zhao J, Tian X, Zhu Y, Zhang Z, Rydkina E, Yuan Y, Zhang H, Roy B, Cornwell A, Nevo E, Shang X, Huang R, Kristiansen K, Seluanov A, Fang X, Gorbunova V. Transformation of naked mole-rat cells. Nature. 2020 Jul;583(7814):E8-E13. doi: 10.1038/s41586-020-2411-9.PMID: 32612220 Free PMC article.   PubMed Link
  • Simon M, Emmrich S, Seluanov A, Gorbunova V. A hairy tale: SIRT7 safeguards skin stem cells during aging. EMBO J. 2020 Sep 15;39(18):e106294. doi: 10.15252/embj.2020106294. Epub 2020 Aug 16.
    PMID: 32803757 PubMed Link
  • Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V. Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Nat Commun.  2020 May 12;11(1):2376. doi: 10.1038/s41467-020-16050-w.  PubMed Link
  • Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 Jul 28;32(4):107949. doi: 10.1016/j.celrep.2020.107949.    PubMed Link
  • Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A, Gorbunova V. SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. Aging (Albany NY) . 2020 Jun 25;12(12):11165-11184. doi: 10.18632/aging.103567  PubMed Link
  • Kumar V, Agrawal R, Pandey A, Kopf S, Hoeffgen M, Kaymak S, Bandapalli OR, Gorbunova V, Seluanov A, Mall MA, Herzig S, Nawroth PP. Compromised DNA repair is responsible for diabetes-associated fibrosis. EMBO J. 2020 Jun 2;39(11):e103477. doi: 10.15252/embj.2019103477. Epub 2020 Apr 27.  PubMed Link
  • Gorbunova V, Seluanov A, Kennedy BK. The World Goes Bats: Living Longer and Tolerating Viruses.Cell Metab. 2020 Jul 7;32(1):31-43. doi: 10.1016/j.cmet.2020.06.013.PMID: 32640245 Free PMC article. Review.  PubMed link
  • Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V. Proteomics of Long-Lived Mammals . 2020 Mar;20(5-6):e1800416. doi: 10.1002/pmic.201800416. Epub 2020 Jan 9. PMID: 31737995 Free PMC article. Review. PubMed Link

2019

  • Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, Kondo A, Wadhwani NR, Lulla R, Goldman S, Venneti S, Becher OJ, Zou L, Shilatifard A, Hashizume R. Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2019 Sep 15;25(18):5572-5583. doi: 10.1158/1078-0432.CCR-18-3890. Epub 2019 Jun 21.PMID: 31227500 Free PMC article.                                                                                                                                                                                                                                                                                                                                                                                                                       PubMed Link 
  • Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P.Publisher Correction: Lipidome determinants of maximal lifespan in mammals. Sci Rep. 2019 May 1;9(1):6972.
    PubMed link
  • Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V. LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metab. 2019 Apr 2;29(4):871-885
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  • Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 Apr 18;177(3):622-638
    PubMed link
  • Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res. . 2019 Sep 19;47(16):8563-8580. doi: 10.1093/nar/gkz592.                                                                                                                                                                                                                                                                                                PubMed link
  • Rezazadeh S, Yang D, Tombline G, Simon M, Regan SP, Seluanov A, Gorbunova V. SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170.  Nucleic Acids Res. . 2019 Sep 5;47(15):7914-7928. doi: 10.1093/nar/gkz528.                                                                                                                                                                                                                                                                                                                                                                                                       PubMed link 
  • De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. (2019). L1 drives IFN in senescent cells and promotes age-associated inflammation.Nature. 2019 Feb; 566(7742):73-78
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2018

  • Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, Imbeault M, Izsvák Z, Levin HL, Macfarlan TS, Mager DL, Feschotte C.  (2018). Ten things you should know about transposable elements. Genome Biol. 2018 Nov 19;19(1):199.
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  • Evdokimov A, Kutuzov M, Petruseva I, Lukjanchikova N, Kashina E, Kolova E, Zemerova T, Romanenko S, Perelman P, Prokopov D, Seluanov A, Gorbunova V, Graphodatsky A, Trifonov V, Khodyreva S, Lavrik O.(2018).  Naked mole rat cells display more efficient excision repair than mouse cells. Aging (Albany NY). 2018 Jun 20;10(6):1454-1473
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  •  Seluanov A, Gladyshev VN, Vijg J, Gorbunova V. (2018).  Mechanisms of cancer resistance in long lived mammals .Nat Rev Cancer. 2018 Jul;18(7):433-441
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  • Ke Z, Seluanov A, Gorbunova V. (2018) Accurate translation is important for fidelity. Aging (Albany NY). 2018 Mar 12;10(3):297-298
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  • Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V. (2018)  Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1801-1806. Pubmed link
  • Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V. (2018). Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741).
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  • Swovick K, Welle KA, Hryhorenko J, Seluanov A, Gorbunova V, Ghaemmaghami S.
    Mol Cell Proteomics. (2018) Cross-species comparison of proteome turnover kinetics.pii: mcp.RA117.000574.
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2017

  • Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V.(2017). Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. 14;9(5):1721-1734.
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  • Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD. (2017). AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. Oncogene. 10.1038/onc.2017.340.
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  • Tian X, Seluanov A, Gorbunova V. (2017). Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species. Trends Endocrinol Metab. (10):722-734.
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  • Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V. (2017). Translation fidelity coevolves with longevity. Aging Cell. 16(5):988-993.
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  • Tian X, Seluanov A, Gorbunova V. (2017) Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. Cell Metab. 2;25(5):991-992.
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  • Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V. (2017) Non-canonical aging model systems and why we need them. EMBO J. 13;36(8):959-963.
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  • Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V.D., Debonneuil, E., et al. (2017). A review of the biomedical innovations for healthy longevity. Aging (Albany NY) 9, 7-25.
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  • Bozek, K., Khrameeva, E.E., Reznick, J., Omerbasic, D., Bennett, N.C., Lewin, G.R., Azpurua, J., Gorbunova, V., Seluanov, A., Regnard, P., et al. (2017). Lipidome determinants of maximal lifespan in mammals. Sci Rep 7, 5.
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2016

  • Gorbunova, V., Rezazadeh, S., and Seluanov, A. (2016). Dangerous Entrapment for NRF2. Cell 165, 1312-1313.
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  • Van Meter, M., Simon, M., Tombline, G., May, A., Morello, T.D., Hubbard, B.P., Bredbenner, K., Park, R., Sinclair, D.A., Bohr, V.A., et al. (2016). JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Rep 16, 2641-2650.
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  • Patrick, A., Seluanov, M., Hwang, C., Tam, J., Khan, T., Morgenstern, A., Wiener, L., Vazquez, J.M., Zafar, H., Wen, R., et al. (2016). Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY) 8, 841-847.
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  • Gorbunova, V., and Seluanov, A. (2016). DNA double strand break repair, aging and the chromatin connection. Mutat Res 788, 2-6.
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  • Ma, S., Upneja, A., Galecki, A., Tsai, Y.M., Burant, C.F., Raskind, S., Zhang, Q., Zhang, Z.D., Seluanov, A., Gorbunova, V., et al. (2016). Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife 5.
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  • Hewitt, G., Carroll, B., Sarallah, R., Correia-Melo, C., Ogrodnik, M., Nelson, G., Otten, E.G., Manni, D., Antrobus, R., Morgan, B.A., et al. (2016). SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy 12, 1917-1930.
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  • Dokukin, M., Ablaeva, Y., Kalaparthi, V., Seluanov, A., Gorbunova, V., and Sokolov, I. (2016). Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM. Biophys J 111, 236-246.
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2015

  • Fang, X., Nevo, E., Han, L., Levanon, E.Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., et al. (2015). Corrigendum:Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun 5, 2015 Aug 12;6:8051. doi: 10.1038/ncomms9051.
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  • Ma, S., Lee, S.G., Kim, E.B., Park, T.J., Seluanov, A., Gorbunova, V., Buffenstein, R., Seravalli, J., and Gladyshev, V.N. (2015). Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep 13, 1319-1326.
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  • MacRae, S.L., Croken, M.M., Calder, R.B., Aliper, A., Milholland, B., White, R.R., Zhavoronkov, A., Gladyshev, V.N., Seluanov, A., Gorbunova, V., et al. (2015a). DNA repair in species with extreme lifespan differences. Aging (Albany NY) 7, 1171-1184.
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  • MacRae, S.L., Zhang, Q., Lemetre, C., Seim, I., Calder, R.B., Hoeijmakers, J., Suh, Y., Gladyshev, V.N., Seluanov, A., Gorbunova, V., et al. (2015b). Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell 14, 288-291.
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  • Xu, Z., Zhang, L., Zhang, W., Meng, D., Zhang, H., Jiang, Y., Xu, X., Van Meter, M., Seluanov, A., Gorbunova, V., et al. (2015). SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle 14, 269-276.
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  • Tian, X., Azpurua, J., Ke, Z., Augereau, A., Zhang, Z.D., Vijg, J., Gladyshev, V.N., Gorbunova, V., and Seluanov, A. (2015). INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A 112, 1053-1058.
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2014

  • Vaidya, A., Mao, Z., Tian, X., Spencer, B., Seluanov, A., and Gorbunova, V. (2014). Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet 10, e1004511.
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  • Van Meter, M., Gorbunova, V., and Seluanov, A. (2014a). SIRT6: a promising target for cancer prevention and therapy. Adv Exp Med Biol 818, 181-196.
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  • Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A.J., Morello, T.D., Seluanov, A., and Gorbunova, V. (2014b). SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun 5, 5011.
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  • Fang, X., Nevo, E., Han, L., Levanon, E.Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., et al. (2014). Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat Commun 5, 3966.
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  • Gorbunova, V., Seluanov, A., Zhang, Z., Gladyshev, V.N., and Vijg, J. (2014). Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet 15, 531-540.
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  • Keane, M., Craig, T., Alfoldi, J., Berlin, A.M., Johnson, J., Seluanov, A., Gorbunova, V., Di Palma, F., Lindblad-Toh, K., Church, G.M., et al. (2014). The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics 30, 3558-3560.
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  • Ke, Z., Vaidya, A., Ascher, J., Seluanov, A., and Gorbunova, V. (2014). Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups. J Am Assoc Lab Anim Sci 53, 89-91.
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  • Hine, C.M., Li, H., Xie, L., Mao, Z., Seluanov, A., and Gorbunova, V. (2014). Regulation of Rad51 promoter. Cell Cycle 13, 2038-2045.
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  • Cao, Y., Xu, Y., Zhang, L., Li, Z., Jiang, Y., Tian, X., Seluanov, A., Gorbunova, V., and Mao, Z. (2014). Utilization of Rad51C promoter for transcriptional targeting of cancer cells. Oncotarget 5, 1805-1811.
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2013

  • Azpurua, J., Ke, Z., Chen, I.X., Zhang, Q., Ermolenko, D.N., Zhang, Z.D., Gorbunova, V., and Seluanov, A. (2013a). Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proc Natl Acad Sci U S A 110, 17350-17355.
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  • Tian, X., Azpurua, J., Hine, C., Vaidya, A., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V., and Seluanov, A. (2013). High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature 499, 346-349.
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  • Azpurua, J., Yang, J.N., Van Meter, M., Liu, Z., Kim, J., Lobo Ladd, A.A., Coppi, A.A., Gorbunova, V., and Seluanov, A. (2013b). IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging (Albany NY) 5, 304-314.
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  • Yang, J.N., Seluanov, A., and Gorbunova, V. (2013). Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging. PLoS One 8, e73318.
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2012

  • Gorbunova, V., Hine, C., Tian, X., Ablaeva, J., Gudkov, A.V., Nevo, E., and Seluanov, A. (2012). Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A 109, 19392-19396.
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  • Mao, Z., Tian, X., Van Meter, M., Ke, Z., Gorbunova, V., and Seluanov, A. (2012b). Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A 109, 11800-11805.
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  • Anisimov, V.N., Bartke, A., Barzilai, N., Batin, M.A., Blagosklonny, M.V., Brown-Borg, H., Budovskaya, Y., Campisi, J., Friguet, B., Fraifeld, V., et al. (2012). The second international conference “genetics of aging and longevity”. Aging (Albany NY) 4, 305-317.
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  • Van Meter, M., Seluanov, A., and Gorbunova, V. (2012). Forever young? Exploring the link between rapamycin, longevity and cancer. Cell Cycle 11, 4296-4297.
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  • Mao, Z., Ke, Z., Gorbunova, V., and Seluanov, A. (2012a). Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY) 4, 431-435.
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  • Hine, C.M., Seluanov, A., and Gorbunova, V. (2012). Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer. Mol Ther 20, 347-355.
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2011

  • Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., and Gorbunova, V. (2011). SIRT6 promotes DNA repair under stress by activating PARP1. Science 332, 1443-1446.
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  • Fong, V., Osterbur, M., Capella, C., Kim, Y.E., Hine, C., Gorbunova, V., Seluanov, A., and Dewhurst, S. (2011). Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PLoS One 6, e28714.
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  • Van Meter, M., Mao, Z., Gorbunova, V., and Seluanov, A. (2011a). Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY) 3, 829-835.
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  • Van Meter, M., Mao, Z., Gorbunova, V., and Seluanov, A. (2011b). SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 10, 3153-3158.
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2010

  • Seluanov, A., Mao, Z., and Gorbunova, V. (2010a). Analysis of DNA double-strand break (DSB) repair in mammalian cells. J Vis Exp.
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  • Seluanov, A., Vaidya, A., and Gorbunova, V. (2010b). Establishing primary adult fibroblast cultures from rodents. J Vis Exp.
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2009

  • Gorbunova, V., and Seluanov, A. (2009). Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev 130, 3-9.
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  • Mao, Z., Jiang, Y., Liu, X., Seluanov, A., and Gorbunova, V. (2009). DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia 11, 683-691.
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  • Seluanov, A., Hine, C., Azpurua, J., Feigenson, M., Bozzella, M., Mao, Z., Catania, K.C., and Gorbunova, V. (2009). Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A 106, 19352-19357.
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2008

  • Seluanov, A., Hine, C., Bozzella, M., Hall, A., Sasahara, T.H., Ribeiro, A.A., Catania, K.C., Presgraves, D.C., and Gorbunova, V. (2008). Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell 7, 813-823.
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  • Hine, C.M., Seluanov, A., and Gorbunova, V. (2008). Use of the Rad51 promoter for targeted anti-cancer therapy. Proc Natl Acad Sci U S A 105, 20810-20815.
    PubMed link
    Journal Link
  • Mao, Z., Bozzella, M., Seluanov, A., and Gorbunova, V. (2008a). Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst) 7, 1765-1771.
    PubMed link
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  • Mao, Z., Bozzella, M., Seluanov, A., and Gorbunova, V. (2008b). DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7, 2902-2906.
    PubMed link
    Journal Link
  • Dion, V., Lin, Y., Price, B.A., Fyffe, S.L., Seluanov, A., Gorbunova, V., and Wilson, J.H. (2008). Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair (Amst) 7, 313-320.
    PubMed link
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  • Gorbunova, V., Bozzella, M.J., and Seluanov, A. (2008). Rodents for comparative aging studies: from mice to beavers. Age (Dordr) 30, 111-119.
    PubMed link
    Journal Link

2007

  • Gorbunova, V., Seluanov, A., Mao, Z., and Hine, C. (2007). Changes in DNA repair during aging. Nucleic Acids Res 35, 7466-7474.
    PubMed link
    Journal Link
  • Mao, Z., Seluanov, A., Jiang, Y., and Gorbunova, V. (2007). TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A 104, 13068-13073.
    PubMed link
    Journal Link
  • Seluanov, A., Chen, Z., Hine, C., Sasahara, T.H., Ribeiro, A.A., Catania, K.C., Presgraves, D.C., and Gorbunova, V. (2007a). Telomerase activity coevolves with body mass not lifespan. Aging Cell 6, 45-52.
    PubMed link
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  • Seluanov, A., Danek, J., Hause, N., and Gorbunova, V. (2007b). Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair (Amst) 6, 1740-1748.
    PubMed link
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  • Shi, X., Seluanov, A., and Gorbunova, V. (2007). Cell divisions are required for L1 retrotransposition. Mol Cell Biol 27, 1264-1270.
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2005

  • Gorbunova, V., and Seluanov, A. (2005). Making ends meet in old age: DSB repair and aging. Mech Ageing Dev 126, 621-628.
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2004

  • Seluanov, A., Mittelman, D., Pereira-Smith, O.M., Wilson, J.H., and Gorbunova, V. (2004). DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci U S A 101, 7624-7629.
    PubMed link
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  • Gorbunova, V., Seluanov, A., Mittelman, D., and Wilson, J.H. (2004). Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells. Hum Mol Genet 13, 2979-2989.
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