Dr. Xiao Tian

Post Doctoral Researcher

My research focuses on identifying molecular mechanisms responsible for exceptional longevity and cancer resistance in long-lived species, including naked mole rat (Heterocephalus glaber), beaver (Castor canadensis), and bowhead whale (Balaena mysticetus). DNA repair mechanisms were compared between long- and short-lived species, which revealed a significant correlation between lifespan and the efficiency of DNA double-strand break (DSB) repair.

High-molecular-weight hyaluronic acid (HMW HA) was identified as a critical anti-cancer mechanism in the naked mole rat. The potential role of HMW HA in promoting longevity in naked mole rats is currently under investigation.